Leigh K Murray

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Cognitive decline is common in older adults, even in the absence of significant medical or neurological conditions. Recent work implicates serum levels of brain-derived neurotrophic factor in age-related cognitive decline, though no study has directly examined this possibility. A total of 35 older adults without neurological history underwent fasting blood(More)
Though elevated beta-amyloid deposition is associated with Alzheimer's disease, recent evidence suggests beta-amyloid is elevated in healthy older adults prior to the onset of Alzheimer's disease. No study has yet investigated whether reduced cognitive function is related to beta-amyloid elevation in healthy older adults. Thirty-five healthy older adults(More)
OBJECTIVES Vascular pathology is associated with reduced performance on neuropsychological tests, particularly in older adults. A likely explanation involves a disruption in the blood brain barrier (BBB). Work from clinical samples show alterations in BBB function is associated with cognitive dysfunction on testing, though no study has examined this(More)
OBJECTIVE It is well established that a combination of factors, including ethnicity, may influence an individual's response to cold stress. Previous work from our laboratory has demonstrated that when faced with a cold challenge, there is a similar response in heat production between Caucasian (CAU) and African American (AA) individuals that is accompanied(More)
BACKGROUND Anterior cruciate ligament (ACL) injury is common among females due to many anatomic, hormonal, and neuromuscular risk factors. One modifiable risk factor that places females at increased risk of ACL injury is a poor hamstrings: quadriceps (H:Q) co-activation ratio, which should be 0.6 or greater in order to decrease the stress placed on the ACL.(More)
Aging is an inevitable process, but the rate and magnitude of the decline in physiologic function may be attenuated by an exercise/activity intervention. The prevalence of chronic disease however increases through the lifespan. Therefore there is a greater need to indirectly assess the individual’s aerobic capacity, muscular strength, body composition,(More)
OBJECTIVE To explore the effect of aspirin on the thermoregulatory responses of men during exposure to 12°C air (acute cold exposure) for a period of 120 minutes and recovery in 25°C air (rewarming) for 120 minutes. METHODS Seven male subjects (26.1 ± 2.4 yr) underwent pre-experimental testing to determine peak VO(2) and body composition. Participants(More)
PURPOSE The purpose of this systematic review was to determine the exercises that optimize muscle ratios of the periscapular musculature for scapular stability and isolated strengthening. METHODS A systematic search was performed in PubMed, CINAHL, SPORTDiscus, Scopus, and Discovery Layer. Studies were included if they examined the muscle activation of(More)
OBJECTIVES Depression has a significant impact on the functioning of older adults and often precedes cognitive decline or dementia. The current study examines the association between biomarkers related to neurocognitive outcome and depression in this population. METHOD Thirty-five older adults without significant neurological or psychiatric history(More)
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