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The Arabidopsis C2H2 Zinc Finger INDETERMINATE DOMAIN1/ENHYDROUS Promotes the Transition to Germination by Regulating Light and Hormonal Signaling during Seed Maturation[W]
The physical interaction of ENY with DELLAs and an ENY-triggered accumulation of DELLA transcripts during maturation support the conclusion that ENY mediates GA effects to balance ABA-promoted maturation during late seed development.
Panx1 regulates neural stem and progenitor cell behaviours associated with cytoskeletal dynamics and interacts with multiple cytoskeletal elements
- Leigh E. Wicki-Stordeur, L. A. Swayne
- Biology, MedicineCell Communication and Signaling
- 21 August 2013
It is demonstrated that Panx1 also plays roles in two additional cell behaviours associated with neurogenesis, including cell migration and neurite extension, and strengthens and expands the knowledge of PanX1 interactions with the cytoskeleton.
ATP stimulates pannexin 1 internalization to endosomal compartments.
- A. K. Boyce, Michelle S Kim, Leigh E. Wicki-Stordeur, L. A. Swayne
- BiologyThe Biochemical journal
- 15 September 2015
Striking evidence is provided that ATP, in turn, stimulates internalization of Panx1 to intracellular membranes and that elevation of ATP levels diverts a sub-population to recycling endosomes.
Pannexin 1 regulates postnatal neural stem and progenitor cell proliferation
- Leigh E. Wicki-Stordeur, A. Dzugalo, Rose M Swansburg, Jocelyne M T Suits, L. A. Swayne
- BiologyNeural Development
- 4 July 2012
It is demonstrated that pannexin 1 regulates neural stem and progenitor cell proliferation likely through the release of adenosine triphosphate (ATP), a potent autocrine/paracine signaling metabolite.
Upregulation of inflammatory mediators in the ventricular zone after cortical stroke
- Adrianna N Gunton, Juan C. Sanchez-Arias, Esther O Carmona-Wagner, Leigh E. Wicki-Stordeur, L. A. Swayne
- BiologyProteomics. Clinical applications
- 1 September 2017
Changes in protein expression in the ipsilateral VZ early (4 h) after stroke are identified to gain insight into the initial mechanisms involved in NPC activation post‐stroke.
Powerful partnership: crosstalk between pannexin 1 and the cytoskeleton
The roles of pannexin 1 (Panx1) large-pore ion and metabolite channels are becoming recognized in many physiological and pathophysiological scenarios and the reciprocal regulation between Panx1 and the cytoskeleton is examined.
Analysis of a pannexin 2-pannexin 1 chimeric protein supports divergent roles for pannexin C-termini in cellular localization
This work uses overlap-extension cloning to create the first chimeric Panx, consisting of Panx2 with the Panx1 C-terminus (Panx2Panx1CT), and is the first to observe a high level of co-localization between Panx 2 and the endolysosomal enriched mannose-6-phosphate receptor.
Pannexin 1 Differentially Affects Neural Precursor Cell Maintenance in the Ventricular Zone and Peri-Infarct Cortex
- Leigh E. Wicki-Stordeur, Juan C. Sanchez-Arias, L. A. Swayne
- BiologyJournal of Neuroscience
- 27 January 2016
It is demonstrated that Pannexin 1 maintains a consistent population size of neural precursor cells in the ventricular zone, both in the healthy brain and in the context of stroke.
The emerging Pannexin 1 signalome: a new nexus revealed?
The reported associations of Panx1 with other ion channels, receptors, and channel signaling complexes are elucidated, and the implications of these protein–protein interactions for PanX1 function in various cell and tissue types are discussed.
Probenecid Disrupts a Novel Pannexin 1-Collapsin Response Mediator Protein 2 Interaction and Increases Microtubule Stability
Probenecid treatment significantly disrupted the Panx1-Crmp2 interaction by both immunoprecipitation and proximity ligation analysis, without altering overall Crmp2 protein expression levels, and increased microtubule stability.