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We have isolated and functionally characterized a multicomponent Oct-1 coactivator, OCA-S which is essential for S phase-dependent histone H2B transcription. The p38 component of OCA-S binds directly to Oct-1, exhibits potent transactivation potential, is selectively recruited to the H2B promoter in S phase, and is essential for S phase-specific H2B(More)
The problem of blind noise level estimation arises in many image processing applications, such as denoising, compression, and segmentation. In this paper, we propose a new noise level estimation method on the basis of principal component analysis of image blocks. We show that the noise variance can be estimated as the smallest eigenvalue of the image block(More)
This paper conducts a content analysis on the performance of information and interactions in selected Chinese government microblog accounts as innovations in the public sector. In specific, the study examines the quantity, content, stakeholders related, government levels related, timeliness, forms, language styles, sources of message, the use of push, and(More)
Noise variance estimation is required in many image denoising, compression, and segmentation applications. In this work, we propose a fast noise variance estimation algorithm based on principal component analysis of image blocks. First, we rearrange image blocks into vectors and compute the covariance matrix of these vectors. Then, we use Bartlett's test in(More)
Vascular endothelial growth factor (VEGF) plays a neuroprotective role in mice harboring mutations of copper-zinc superoxide dismutase 1 (SOD1) in familial amyotrophic lateral sclerosis (ALS). Conversely, the loss of VEGF expression through genetic depletion can give rise to a phenotype resembling ALS independent of SOD1 mutations. Here, we observe a(More)
Voluntary exercise has tremendous effects on adult hippocampal plasticity and metabolism and thus sculpts the hippocampal structure of mammals. High-field (1)H magnetic resonance (MR) investigations at 9.4 T of metabolic and structural changes can be performed non-invasively in the living rodent brain. Numerous molecular and cellular mechanisms mediating(More)
The aggressiveness of pancreatic ductal adenocarcinoma (PDA) is characterized by its high metastatic potential and lack of effective therapies, which is the result of a lack of understanding of the mechanisms involved in promoting PDA metastases. We identified Annexin A2 (ANXA2), a member of the Annexin family of calcium-dependent phospholipid binding(More)
This study comprises a comparative analysis between the US and China regarding public sector leadership behaviors in the context of cross-boundary information sharing and integration. The research conducts an original case study in China set in the product safety and food safety policy domain. The case explores leadership behaviors of middle-level(More)
Ca(2+) efflux by Ca(2+) cation antiporter (CaCA) proteins is important for maintenance of Ca(2+) homeostasis across the cell membrane. Recently, the monomeric structure of the prokaryotic Na(+)/Ca(2+) exchanger (NCX) antiporter NCX_Mj protein from Methanococcus jannaschii shows an outward-facing conformation suggesting a hypothesis of alternating substrate(More)
This paper presents an attempt at building a large scale distributed composite language model that is formed by seamlessly integrating an n-gram model, a structured language model, and probabilistic latent semantic analysis under a directed Markov random field paradigm to simultaneously account for local word lexical information, mid-range sentence(More)