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Epigallocatechin Gallate Is the Most Effective Catechin Against Antioxidant Stress via Hydrogen Peroxide and Radical Scavenging Activity
TLDR
Epigallocatechin gallate is the most effective antioxidant polyphenol against hydrogen peroxide and radical-scavenging activity, and results suggest that beneficial effects were strongly related with structure of catechins, mainly because of the hydroxyl and galloyl groups. Expand
Dietary Melatonin Therapy Alleviates the Lamina Cribrosa Damages in Patients with Mild Cognitive Impairments: A Double-Blinded, Randomized Controlled Study
TLDR
Dietary melatonin therapy could provide an effective medication for MCI patients with LCT alterations and might allow early diagnosis of MCI. Expand
Adeno‐associated virus (AAV)‐mediated neuroprotective effects on the degenerative retina: the therapeutic potential of erythropoietin
TLDR
Beneficial results suggest the AAV vector is a viable therapeutic option for retinopathies with rapidly degenerating kinetics and lay the groundwork for future development of EPO gene therapy. Expand
Vascular Risk Factors and Alzheimer's Disease: Blood-Brain Barrier Disruption, Metabolic Syndromes, and Molecular Links.
TLDR
Key vascular risk factors for AD are enlightened and pathophysiologic relationship between AD and vascular dysfunction is highlighted and APOE polymorphic alleles that characterize impaired cerebrovascular integrity function as primary genetic determinants of AD are highlighted. Expand
RNA sequencing uncovers the key long non-coding RNAs and potential molecular mechanism contributing to XAV939-mediated inhibition of non-small cell lung cancer
TLDR
The downregulation of lncRNA MIR503HG induced by XAV939 may serve an important role in NSCLC suppression via sponging miR-1273c and regulating SOX4 expression and the down regulation of SLC7A11 induced byXAV 939 may also inhibit the development of NSCLc via the ferroptosis pathway. Expand
Expression changes of the notch signaling pathway of PC12 cells after oxygen glucose deprivation.
TLDR
It is suggested that OGD exposure up-regulates the expression of Notch1, Hes1 and Hes5, which are important participants in Notch signaling pathway, which may play an important role in cerebral ischemic injury. Expand
Anti-oxidative effects of catechins and theaflavins on glutamate-induced HT22 cell damage
Background: Glutamate is an excitatory neurotransmitter that is involved in cell stress caused by oxidation. Polyphenolic compounds display various potential neuroprotective properties due to theirExpand
Mindfulness-based stress reduction in patients with differentiated thyroid cancer receiving radioactive iodine therapy: a randomized controlled trial
TLDR
An 8-week MBSR program significantly improved a wide range of scales in health-related QoL and mitigated depression and anxiety among DTC patients receiving RIT. Expand
Elevated Notch1 enhances interleukin-22 production by CD4+ T cells via aryl hydrocarbon receptor in patients with lung adenocarcinoma
TLDR
It is indicated that elevated Notch1 induced higher IL-22 secretion by CD4+ T cells in lung adenocarcinoma patients, and Notch-AhR-IL-22 axis took part in the pathogenesis of lungAdenocARCinoma. Expand
Knockdown of microRNA-17-5p Enhances the Neuroprotective Effect of Act A/Smads Signal Loop After Ischemic Injury
Cerebral ischemic injury is a leading cause of human mortality and disability, seriously threatening human health in the world. Activin A (Act A), as a well-known neuroprotective factor, couldExpand
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