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  • George T Grossberg, Facundo Manes, +8 authors Stephen M Graham
  • Medicine
  • CNS Drugs
  • 2013 (First Publication: 1 June 2013)
  • IntroductionImmediate-release memantine (10 mg, twice daily) is approved in the USA for moderate-to-severe Alzheimer’s disease (AD). This study evaluated the efficacy, safety, and tolerability of aContinue Reading
  • Christopher L Tang, Lei Xie, Ingrid Y. Y. Koh, Shoshana L. Posy, Emil Alexov, Barry Honig
  • Biology, Medicine
  • Journal of molecular biology
  • 2003 (First Publication: 1 December 2003)
  • Structural alignments often reveal relationships between proteins that cannot be detected using sequence alignment alone. However, profile search methods based entirely on structural alignments aloneContinue Reading
  • Sarah L. Kinnings, Nina Liu, Nancy Buchmeier, Peter J. Tonge, Lei Xie, Philip E. Bourne
  • Medicine, Biology, Computer Science
  • PLoS Computational Biology
  • 2009 (First Publication: 1 July 2009)
  • The rise of multi-drug resistant (MDR) and extensively drug resistant (XDR) tuberculosis around the world, including in industrialized nations, poses a great threat to human health and defines a needContinue Reading
  • Li Xie, Jerry Li, Lei Xie, Philip E. Bourne
  • Medicine, Biology, Computer Science
  • PLoS Computational Biology
  • 2009 (First Publication: 1 May 2009)
  • Systematic identification of protein-drug interaction networks is crucial to correlate complex modes of drug action to clinical indications. We introduce a novel computational strategy to identifyContinue Reading
  • Sarah L. Kinnings, Nina Liu, Peter J. Tonge, Richard M. Jackson, Lei Xie, Philip E. Bourne
  • Computer Science, Medicine, Chemistry
  • J. Chem. Inf. Model.
  • 2011 (First Publication: 28 February 2011)
  • Docking scoring functions are notoriously weak predictors of binding affinity. They typically assign a common set of weights to the individual energy terms that contribute to the overall energyContinue Reading
  • Li Xie, Thomas Evangelidis, Lei Xie, Philip E. Bourne
  • Biology, Medicine, Computer Science
  • PLoS Computational Biology
  • 2011 (First Publication: 1 April 2011)
  • Nelfinavir is a potent HIV-protease inhibitor with pleiotropic effects in cancer cells. Experimental studies connect its anti-cancer effects to the suppression of the Akt signaling pathway, but theContinue Reading
  • Lei Xie, Li Xie, Philip E. Bourne
  • Computer Science, Medicine
  • Bioinform.
  • 2009 (First Publication: 27 May 2009)
  • Functional relationships between proteins that do not share global structure similarity can be established by detecting their ligand-binding-site similarity. For a large-scale comparison, it isContinue Reading