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Despite efforts to profile prostate cancer, the genetic alterations and biological processes that correlate with the observed histological progression are unclear. Using laser-capture microdissection to isolate 101 cell populations, we have profiled prostate cancer progression from benign epithelium to metastatic disease. By analyzing expression signatures(More)
In this paper, we present the mQA model, which is able to answer questions about the content of an image. The answer can be a sentence, a phrase or a single word. Our model contains four components: a Long Short-Term Memory (LSTM) to extract the question representation, a Convolutional Neural Network (CNN) to extract the visual representation, an LSTM for(More)
Recently, we identified recurrent gene fusions involving the 5' untranslated region of the androgen-regulated gene TMPRSS2 and the ETS (E26 transformation-specific) family genes ERG, ETV1 or ETV4 in most prostate cancers. Whereas TMPRSS2-ERG fusions are predominant, fewer TMPRSS2-ETV1 cases have been identified than expected on the basis of the frequency of(More)
In the literature of feature selection, different criteria have been proposed to evaluate the goodness of features. In our investigation, we notice that a number of existing selection criteria implicitly select features that preserve sample similarity, and can be unified under a common framework. We further point out that any feature selection criteria(More)
More than 1,000,000 men undergo prostate biopsy each year in the United States, most for "elevated" serum prostate-specific antigen (PSA). Given the lack of specificity and unclear mortality benefit of PSA testing, methods to individualize management of elevated PSA are needed. Greater than 50% of PSA-screened prostate cancers harbor fusions between the(More)
Recent developments in smart grid technology have spawned interest in the use of phasor measurement units to help create a reliable power system transmission and distribution infrastructure. Wide-area monitoring systems (WAMSs) utilizing synchrophasor measurements can help with understanding, forecasting, or even controlling the status of power grid(More)
MOTIVATION Current high-throughput protein-protein interaction (PPI) data do not provide information about the condition(s) under which the interactions occur. Thus, the identification of condition-responsive PPI sub-networks is of great importance for investigating how a living cell adapts to changing environments. RESULTS In this article, we propose a(More)
Hepatic resection (HR) is the only option offering a potential cure for patients with synchronous colorectal cancer liver metastases (SCRLM). The optimal timing of HR for SCRLM is still controversial. This study aimed to determine whether simultaneous HR is similar to staged resection regarding the morbidity and mortality rates in patients with SCRLM. Four(More)
In this paper, we present the mQA model, which is able to answer questions about the content of an image. The answer can be a sentence, a phrase or a single word. Our model contains four components: a Long Short-Term Memory (LSTM) to extract the question representation, a Convolutional Neural Network (CNN) to extract the visual representation, an LSTM for(More)