Learn More
Astrocytes have a higher antioxidant potential in comparison to neurons. Pathways associated with this selective advantage include the transcriptional regulation of antioxidant enzymes via the action of the Cap'n'Collar transcription factor Nrf2 at the antioxidant response element (ARE). Here we show that Nrf2 overexpression can reengineer neurons to(More)
3D die stacking is an exciting new technology that increases transistor density by vertically integrating two or more die with a dense, high-speed interface. The result of 3D die stacking is a significant reduction of interconnect both within a die and across dies in a system. For instance, blocks within a microprocessor can be placed vertically on multiple(More)
This paper presented a new approach for robust segmenta-tion of Magnetic Resonance images that have been corrupted by intensity inhomogeneities and noise. The algorithm is formulated by modifying the objective function of the standard fuzzy C-means (FCM) method to compensate for intensity inhomogeneities. A additional term is injected into the objective(More)
A major challenge in human genetics is to devise a systematic strategy to integrate disease-associated variants with diverse genomic and biological data sets to provide insight into disease pathogenesis and guide drug discovery for complex traits such as rheumatoid arthritis (RA). Here we performed a genome-wide association study meta-analysis in a total of(More)
Phase change memory (PCM) recently has emerged as a promising technology to meet the fast growing demand for large capacity memory in modern computer systems. In particular, multi-level cell (MLC) PCM that stores multiple bits in a single cell, offers high density with low per-byte fabrication cost. However, despite many advantages, such as good scalability(More)
As a promising nonvolatile memory technology, Phase Change Memory (PCM) has many advantages over traditional DRAM. Multi-level Cell PCM (MLC) has the benefit of increased memory capacity with low fabrication cost. Due to high per-cell write power and long write latency, MLC PCM requires careful power management to ensure write reliability. Unfortunately,(More)
Phase Change Memory (PCM) has recently emerged as a promising nonvolatile memory technology. To effectively increase memory capacity and reduce per bit fabrication cost, multi-level cell (MLC) PCM stores more than one bit per cell by differentiating multiple intermediate resistance levels. However, MLC PCM suffers from significantly shortened endurance due(More)
STT-MRAM (Spin-Transfer Torque Magnetic RAM) has recently emerged as one of the most promising memory technologies for constructing large capacity last level cache (LLC) of low power mobile processors. With fast technology scaling, STT-MRAM read operations will become destructive such that post-read restores are inevitable to ensure data reliability.(More)
BACKGROUND Metabolites of arachidonic acid such as prostacyclin (PGI2) have been shown to participate in the pathogenesis of pulmonary fibrosis by inhibiting the expression of pro-inflammatory and pro-fibrotic mediators. In this investigation, we examined whether iloprost, a stable PGI2 analogue, could prevent bleomycin-induced pulmonary inflammation and(More)