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This paper seeks to understand how network failures affect the availability of service delivery across wide-area networks (WANs) and to evaluate classes of techniques for improving end-to-end service availability. Using several large-scale connectivity traces, we develop a model of network unavailability that includes key parameters such as failure location(More)
BACKGROUND A number of molecular epidemiological studies have been conducted to explore the association of human papillomavirus (HPV) infection with laryngeal cancer. However, the findings are heterogeneous. METHODS We systematically reviewed studies on HPV infection and laryngeal cancer published up to 15 May 2012 and quantitatively summarized the(More)
In neurons, L-type calcium channels (CaV1.2 and CaV1.3) regulate an extensive range of functions. However, the roles of CaV1.3-containing L channels, which are physiologically and pharmacologically distinct from the better understood CaV1.2 channels, are only beginning to be determined. We find that CaV1.3 channels are modulated by the insulin-like growth(More)
Despite the ubiquity of ammonium in geothermal environments and the thermodynamic favorability of aerobic ammonia oxidation, thermophilic ammonia-oxidizing microorganisms belonging to the crenarchaeota kingdom have only recently been described. In this study, we analyzed microbial mats and surface sediments from 21 hot spring samples (pH 3.4 to 9.0;(More)
Widely regarded as a specific and potent inhibitor of CaM kinases, especially CaMKII, KN93 has long been used to investigate the possible roles of CaMKII in a wide range of biological functions and systems, such as cultured cells, primary neurons, and brain slices. However, here we present evidence showing that KN93 and its structural analog KN92, which(More)
BACKGROUND Ferns have generally been neglected in studies of chloroplast genomics. Before this study, only one polypod and two basal ferns had their complete chloroplast (cp) genome reported. Tree ferns represent an ancient fern lineage that first occurred in the Late Triassic. In recent phylogenetic analyses, tree ferns were shown to be the sister group of(More)
We have determined the complete chloroplast (cp) genome sequence of Cephalotaxus oliveri. The genome is 134,337 bp in length, encodes 113 genes, and lacks inverted repeat (IR) regions. Genome-wide mutational dynamics have been investigated through comparative analysis of the cp genomes of C. oliveri and C. wilsoniana. Gene order transformation analyses(More)
Current serving systems lack the ability to bulk load massive immutable data sets without affecting serving performance. The performance degradation is largely due to index creation and modification as CPU and memory resources are shared with request serving. We have extended Project Voldemort, a general-purpose distributed storage and serving system(More)
We present PRACTI, a new approach for large-scale replication. PRACTI systems can replicate or cache any subset of data on any node (Partial Replication), provide a broad range of consistency guarantees (Arbitrary Consistency), and permit any node to send information to any other node (Topology Independence). A PRACTI architecture yields two significant(More)
Next-generation grid systems where the emphasis shifts to distributed global collaboration, a service-oriented approach, and information layer issues exhibit a strong sense of automation. Requirements for these systems resemble the self-organizing and the self-healing properties of natural ecosystems. Inspired by this resemblance, we introduce some key(More)