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Variants of the vitamin D binding protein (VDBP) gene appear to be associated with levels of the main circulating vitamin D metabolite, 25-hydroxyvitamin D [(25(OH)D]. We examined the associations between the common variants of the VDBP (GC) gene and concentrations of 25(OH)D in a sample of young Canadian adults of East Asian, European and South Asian(More)
The classical Kloosterman sums give rise to a Galois representation of the function field unramfied outside 0 and ∞. We study the local monodromy of this representation at ∞ using l-adic method based on the work of Deligne and Katz. As an application, we determine the degrees and the bad factors of the L-functions of the symmetric products of the above(More)
Perifosine is an alkylphospholipid exhibiting antitumor activity as shown in both preclinical studies and clinical trials. This activity is partly associated with its ability to inhibit Akt activity. It has been shown that the mammalian target of rapamycin (mTOR) axis plays a critical role in regulation of cell proliferation and survival primarily through(More)
OBJECTIVES To assess allele frequency and genotype distribution of CYP2C9 polymorphisms in patients (n = 189) attending an anticoagulant clinic in comparison to control patients (n = 177) and also to assess if the patients with variant genotypes require lower doses of warfarin. METHODS Genotyping of the common CYP2C9 variants *2 and *3 was carried out by(More)
BACKGROUND To determine the effect of vitamin D binding protein (DBP) genotypes on 25-hydroxyvitamin D [25(OH)D] changes with vitamin D supplements, we studied 98 adults receiving 600 or 4000 IU/d vitamin D(3) for one year. METHODS The DBP functional variant, T436K, was genotyped by polymerase chain reaction-restriction fragment length polymorphism(More)
Ursolic acid (UA) is a sort of pentacyclic triterpenoid carboxylic acid purified from natural plant. UA has a series of biological effects such as sedative, anti-inflammatory, anti-bacterial, anti-diabetic, antiulcer, etc. It is discovered that UA has a broad-spectrum anti-tumor effect in recent years, which has attracted more and more scholars' attention.(More)
OBJECTIVES To assess allele frequency and potential predictive value of recurrent polymorphisms affecting warfarin metabolism in an unselected patient cohort attending an anticoagulant clinic (n=186). DESIGN AND METHODS Genotyping of ten SNPs in five candidate genes (VKORC1, CYP2C9, CALU, EPHX and GGCX) was carried out by ABI PRISM SNaPshot multiplex(More)
Uninephrectomy would induce compensatory hypertrophy in the remaining kidney. We investigated the relationship between changes in renal parenchymal volume (RPV) and renal function after nephrectomy in living kidney donors. From July 2011 and January 2012, 45 kidney donors were enrolled in this study. Magnetic resonance scanning was performed before surgery,(More)
The global tuberculosis crisis urgently demands new, efficacious, orally available drugs with the potential to shorten and simplify the long and complex treatments for drug-sensitive and drug-resistant disease. Clofazimine, a riminophenazine used for many years to treat leprosy, demonstrates efficacy in animal models of tuberculosis via a novel mode of(More)
  • Lei Fu
  • International Conference on Information Science…
  • 2011
With the improvement of living standards, shopping malls are bigger after constructing with more abundant goods and more variety of wares. Therefore, building a simple, fast and convenient shopping guide system has become a mutual concern of merchants and customers. In view of the mobile phone has become a popular consumer products, a simple optimization(More)