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BACKGROUND Chemotherapy is an important component in the treatment paradigm for breast cancers. However, the resistance of cancer cells to chemotherapeutic agents frequently results in the subsequent recurrence and metastasis. Identification of molecular markers to predict treatment outcome is therefore warranted. The aim of the present study was to(More)
Four-dimensional (4D) radiotherapy is the explicit inclusion of the temporal changes in anatomy during the imaging, planning, and delivery of radiotherapy. One key component of 4D radiotherapy planning is the ability to automatically ("auto") create contours on all of the respiratory phase computed tomography (CT) datasets comprising a 4D CT scan, based on(More)
Users of mobile devices often need to use those devices in contexts which leave only one hand available for manipulating the device, such as holding another device or manual, walking or operating some machinery.In this paper we discuss the results of a comparison of the effectiveness, efficiency and preference users have for map navigation tasks on a PDA,(More)
BACKGROUND Paroxysmal kinesigenic choreoathetosis (PKC) is characterised by recurrent and brief attacks of involuntary movement, inherited as an autosomal dominant trait with incomplete penetrance. A PKC locus has been previously mapped to the pericentromeric region of chromosome 16 (16p11.2-q12.1), but the causative gene remains unidentified. (More)
Intensity modulated radiation therapy (IMRT) poses a number of challenges for properly measuring commissioning data and quality assurance (QA) radiation dose distributions. This report provides a comprehensive overview of how dosimeters, phantoms, and dose distribution analysis techniques should be used to support the commissioning and quality assurance(More)
The looming potential of deformable alignment tools to play an integral role in adaptive radiotherapy suggests a need for objective assessment of these complex algorithms. Previous studies in this area are based on the ability of alignment to reproduce analytically generated deformations applied to sample image data, or use of contours or bifurcations as(More)
OBJECTIVE To explore the distribution and role of motilin receptor in the amygdala of rats. METHODS The distribution of motilin receptor in the amygdala was detected by immunohistochemistry in adult SD rats of either sex. The duodenal interdigestive migrating myoelectric complex (MMC) was recorded and analyzed for investigating the role of motilin(More)
In this paper, we describe a set of experiments to examine the effect of various attributes of web genre on the automatic identification of the genre of web pages. Four different genres are used in the data set, namely, FAQ, News, E-Shopping and Personal Home Pages. The effects of the number of features used to represent the web pages (5, 20, or 100) as(More)
Influenza A viruses (IAVs), particularly H1N1, H5N1 and H7N9, pose a substantial threat to public health worldwide. Here, we report that MIR2911, a honeysuckle (HS)-encoded atypical microRNA, directly targets IAVs with a broad spectrum. MIR2911 is highly stable in HS decoction, and continuous drinking or gavage feeding of HS decoction leads to a significant(More)
An increased population of CD4(+)CD25(high)Foxp3(+) regulatory T cells (Tregs) in the tumor-associated microenvironment plays an important role in cancer immune evasion. However, the underlying mechanism remains unclear. Here we observed an increased secretion of miR-214 in various types of human cancers and mouse tumor models. Tumor-secreted miR-214 was(More)