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  • Jing Shi, Rachel Knevel, +9 authors Leendert A Trouw
  • Medicine
  • Proceedings of the National Academy of Sciences
  • 2011 (First Publication: 10 October 2011)
  • Autoimmune responses against posttranslationally modified antigens are a hallmark of several autoimmune diseases. For example, antibodies against citrullinated protein antigens (ACPA) have shownExpand
  • Wei Xu, Stefan Philip Berger, +5 authors Cees van Kooten
  • Biology, Medicine
  • The Journal of Immunology
  • 2008 (First Publication: 1 June 2008)
  • Cells that undergo apoptosis or necrosis are promptly removed by phagocytes. Soluble opsonins such as complement can opsonize dying cells, thereby promoting their removal by phagocytes and modulatingExpand
  • Leendert A Trouw, Tom W. L. Groeneveld, +8 authors Mohamed R. Daha
  • Medicine
  • The Journal of clinical investigation
  • 2004 (First Publication: 1 September 2004)
  • Anti-C1q autoantibodies are present in sera of patients with several autoimmune diseases, including systemic lupus erythematosus (SLE). Strikingly, in SLE the presence of anti-C1q is associated withExpand
  • Leendert A Trouw, Anders A.A. Bengtsson, Kyra A. Gelderman, Björn Dahlbäck, Gunnar Sturfelt, Anna M. Blom
  • Medicine, Biology
  • Journal of Biological Chemistry
  • 2007 (First Publication: 28 September 2007)
  • Apoptotic cells have been reported to down-regulate membrane-bound complement regulatory proteins (m-C-Reg) and to activate complement. Nonetheless, most apoptotic cells do not undergoExpand
  • Xia Jiang, Leendert A Trouw, +13 authors Diane van der Woude
  • Medicine
  • Annals of the rheumatic diseases
  • 2014 (First Publication: 8 May 2014)
  • Introduction In rheumatoid arthritis (RA), several genetic risk factors and smoking are strongly associated with the presence of anticitrullinated protein antibodies (ACPA), while much less is knownExpand