Leena Karhinen

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A recent trend in drug development is to identify drug combinations or multi-target agents that effectively modify multiple nodes of disease-associated networks. Such polypharmacological effects may reduce the risk of emerging drug resistance by means of attacking the disease networks through synergistic and synthetic lethal interactions. However, due to(More)
Triple negative breast cancer (TNBC) is a highly heterogeneous and aggressive type of cancer that lacks effective targeted therapy. Despite detailed molecular profiling, no targeted therapy has been established. Hence, with the aim of gaining deeper understanding of the functional differences of TNBC subtypes and how that may relate to potential novel(More)
Comparison of the translational properties of Cocksfoot mottle virus 5'leader sequence with known translational enhancers from other plant viruses. (Manuscript) II Mäkeläinen K., and Mäkinen K. Testing of internal initiation via dicistronic constructs is complicated by production of extraneous transcripts. (Submitted) of VPg and the polyprotein processing(More)
Seipin is an endoplasmic reticulum (ER) membrane protein implicated in lipid droplet (LD) biogenesis and mutated in severe congenital lipodystrophy (BSCL2). Here, we show that seipin is stably associated with nascent ER-LD contacts in human cells, typically via one mobile focal point per LD Seipin appears critical for such contacts since ER-LD contacts were(More)
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