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Opioid substitution and antagonist therapy trials exclude the common addiction patient: a systematic review and analysis of eligibility criteria
BackgroundEligibility criteria that result in the exclusion of a substantial number of patients from randomized trials jeopardize the generalizability of treatment effect to much of the clinicalExpand
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A Prospective Study to Investigate Predictors of Relapse among Patients with Opioid Use Disorder Treated with Methadone
Introduction Concomitant opioid abuse is a serious problem among patients receiving methadone maintenance treatment (MMT) for opioid use disorder. This is an exploratory study that aims to identifyExpand
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The effectiveness of opioid substitution treatments for patients with opioid dependence: a systematic review and multiple treatment comparison protocol
BackgroundOpioids are psychoactive analgesic drugs prescribed for pain relief and palliative care. Due to their addictive potential, effort and vigilance in controlling prescriptions is needed toExpand
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Digital Rectal Examination for Prostate Cancer Screening in Primary Care: A Systematic Review and Meta-Analysis
PURPOSE Although the digital rectal examination (DRE) is commonly performed to screen for prostate cancer, there is limited data to support its use in primary care. This review and meta-analysis aimsExpand
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The association between age of onset of opioid use and comorbidity among opioid dependent patients receiving methadone maintenance therapy
BackgroundOpioid use disorder (OUD) affects approximately 21.9 million people worldwide. This study aims to determine the association between age of onset of opioid use and comorbid disorders, bothExpand
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The impact of comorbid psychiatric disorders on methadone maintenance treatment in opioid use disorder: a prospective cohort study
Objective There is a significant interindividual variability in treatment outcomes in methadone maintenance treatment (MMT) for opioid use disorder (OUD). This prospective cohort study examines theExpand
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Impact of Chronic Pain on Treatment Prognosis for Patients with Opioid Use Disorder: A Systematic Review and Meta-analysis
Background While a number of pharmacological interventions exist for the treatment of opioid use disorder, evidence evaluating the effect of pain on substance use behavior, attrition rate, andExpand
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The "Infodemic" of Journal Publication Associated with the Novel Coronavirus Disease.
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The association between cannabis use and suicidal behavior in patients with psychiatric disorders: an analysis of sex differences
BackgroundCannabis is the most commonly used illicit drug. In the general population, its use has been linked to a heightened propensity for suicidal behavior (SB). We hypothesize that thisExpand
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Return to Sport After Surgical Management of Proximal Hamstring Avulsions: A Systematic Review and Meta-analysis.
OBJECTIVE To assess the rates and timing of return to sport for the surgical management of proximal hamstring avulsions (PHAs). METHODS Three databases, PubMed, MEDLINE, and EMBASE, were searchedExpand
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