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Deriving a function that maps one image on to another similar image is a useful method in medical imaging. The modelling of this deformation function in terms of a functional basis leads to numerical methods of obtaining a good deformation. It is advantageous to be able to represent a wide class commonly observed deformations economically, i.e. where most(More)
OBJECTIVE To determine whether home based medication review by pharmacists affects hospital readmission rates among older people. DESIGN Randomised controlled trial. SETTING Home based medication review after discharge from acute or community hospitals in Norfolk and Suffolk. PARTICIPANTS 872 patients aged over 80 recruited during an emergency(More)
OBJECTIVES To examine objectively spatial patterns of osteophytes around the distal end of the femur and to identify distinct subgroups. METHODS A sample of 107 human femora from a large skeletal population were selected for study. These femora included subjects with evidence of late stage osteoarthritis (that is, with eburnation present) and those with(More)
OBJECTIVE To evaluate the effectiveness of a voluntary sector based befriending scheme in improving psychological wellbeing and quality of life for family carers of people with dementia. DESIGN Single blind randomised controlled trial. SETTING Community settings in East Anglia and London. PARTICIPANTS 236 family carers of people with primary(More)
BACKGROUND Wegener's granulomatosis (WG), Churg Strauss syndrome (CSS) and microscopic polyangiitis (MPA) are primary systemic vasculitides (PSV), the clinical features of which have been described from tertiary centres. AIM To provide the first clinical description of MPA from a general hospital and compare clinical features with WG and CSS. DESIGN(More)
BACKGROUND Several clinical measures of sensory and motor function are used alongside patient-rated questionnaires to assess outcomes of carpal tunnel decompression. However there is a lack of evidence regarding which clinical tests are most responsive to clinically important change over time. METHODS In a prospective cohort study 63 patients undergoing(More)
Locognosia, the ability to localise touch, is one aspect of tactile spatial discrimination which relies on the integrity of peripheral end-organs as well as the somatosensory representation of the surface of the body in the brain. The test presented here is a standardised assessment which uses a protocol for testing locognosia in the zones of the hand(More)
BACKGROUND The General Medical Council expects UK medical graduates to gain some statistical knowledge during their undergraduate education; but provides no specific guidance as to amount, content or teaching method. Published work on statistics teaching for medical undergraduates has been dominated by medical statisticians, with little input from the(More)
AIMS Older people increasingly constitute a large proportion of the acute coronary syndrome (ACS) population. We examined the relationship of age with receipt of more intensive management and secondary prevention medicine. Then, the comparative association of intensive management (reperfusion/angiography) over a conservative strategy on time to death was(More)