Lee R. Ferguson

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OBJECTIVE To report normative data for retinal thickness in wild-type C57BL/6 mouse utilizing a miniature SD-OCT system. METHODS THIRTY ADULT MICE (RANGE: 3-5 months) were anesthetized and secured into the Bioptigen Spectral Domain Ophthalmic Imaging System. Right eye SD-OCT images were standardized by centralizing the optic nerve head (ONH) prior to(More)
The lens and retina of the human eye are exposed constantly to light and oxygen. In situ phototransduction and oxidative phosphorylation within photoreceptors produces a high level of phototoxic and oxidative related stress. Within the eye, the carotenoids lutein and zeaxanthin are present in high concentrations in contrast to other human tissues. We(More)
PURPOSE. Hypoxia-induced apoptosis is responsible for reduced retinal ganglion cell (RGC) viability in a variety of chronic ocular disorders. Sirtuin 1 (SIRT1) plays an important role in preserving cell viability during hypoxia. We investigated the role of SIRT1 in sustaining RGC viability in an in vitro model of hypoxia. METHODS.(More)
BACKGROUND Central corneal thickness (CCT) can be measured by using contact and non-contact methods. Ultrasound pachymetry (US pachymetry) is a contact method for measuring CCT and is perhaps the most commonly used method. However, non-contact methods like scanning slit topography (Orbscan II), slit-lamp optical coherence tomography (SL-OCT), and specular(More)
This protocol outlines and evaluates a modified scanning procedure for a customized spectral domain optical coherence tomography (SD-OCT) imaging apparatus within the wild-type C57Bl/6 mouse posterior segment. This modified protocol allows for the capture of a 50 degree field of view spanning 3 mm by 3 mm perimeter with the optic disc as the central point.(More)
Analyzing raw data can be prohibitively time consuming. A variety of graphical techniques have been developed to address this problem. Although graphical analysis can provide a simple yet comprehensive overview of a large dataset, often these techniques fail to capture the essence of data trends. In addition, the ability to easily query any component of the(More)
BACKGROUND This study determines 'correlation constants' between the gold standard histological measurement of retinal thickness and the newer spectral-domain optical coherence tomography (SD-OCT) technology in adult C57BL/6 mice. METHODS Forty-eight eyes from adult mice underwent SD-OCT imaging and then were histologically prepared for frozen sectioning(More)
BACKGROUND The retinal pigment epithelium (RPE), an important tissue monolayer of retina, sustains visual function and retinal homeostasis. In disease conditions such as Retinitis Pigmentosa (RP) and Age related Macular degeneration (AMD), the integrity and functional capacity of RPE monolayer is compromised. Human embryonic stem cells derived RPE(More)
Le kiwi est par définition une baie : il possède un grand nombre de graines incluses dans une chair comestible. Le kiwi a pour nom latinActinidia et il y a principalement deux espèces d’Actinidia :Actinidia chinensis etActinidia deliciosa. Le kiwi n’est pas seulement un fruit agréable à manger, il est aussi une source exceptionnellement riche en diverses(More)
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