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  • Yansheng Du, Zhi-qing Ma, +11 authors Steven M Paul
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 2001 (First Publication: 4 December 2001)
  • Parkinson's disease is a chronic neurodegenerative disorder characterized by the loss of dopamine neurons in the substantia nigra, decreased striatal dopamine levels, and consequent extrapyramidalContinue Reading
  • Frank P. Bymaster, Wei Zhang, +5 authors Kenneth W. Perry
  • Psychology, Medicine
  • Psychopharmacology
  • 2001 (First Publication: 1 April 2002)
  • Rationale: The selective serotonin uptake inhibitor (SSRI) fluoxetine has been shown to not only increase the extracellular concentrations of serotonin, but also dopamine and norepinephrineContinue Reading
  • Paul A. Hyslop, Zhiyuan Zhang, D. Pearson, Lee Phebus
  • Medicine, Biology
  • Brain Research
  • 1995 (First Publication: 1 February 1995)
  • Toxic reactive oxygen species have been implicated as important mediators of tissue injury after reperfusion of ischemic organs. When rats are subject to 30 min global forebrain ischemia, 24 hContinue Reading
  • Brianne Weiss, Andrew Alt, +21 authors David Bleakman
  • Chemistry, Medicine
  • The Journal of pharmacology and experimental…
  • 2006 (First Publication: 1 August 2006)
  • The excitatory neurotransmitter glutamate has been implicated in both migraine and persistent pain. The identification of the kainate receptor GLU(K5) in dorsal root ganglia, the dorsal horn, andContinue Reading
  • Garth E. Terry, Jeih-San Liow, +12 authors Robert B. Innis
  • Psychology, Medicine, Computer Science
  • NeuroImage
  • 2009 (First Publication: 1 November 2009)
  • [11C]MePPEP is a high affinity, CB1 receptor-selective, inverse agonist that has been studied in rodents and monkeys. We examined the ability of [11C]MePPEP to quantify CB1 receptors in human brainContinue Reading
  • Lee Phebus, Kirk W. Johnson, +8 authors Michael Edward Flaugh
  • Chemistry, Medicine
  • Life sciences
  • 1997 (First Publication: 1 October 1997)
  • LY344864 is a selective receptor agonist with an affinity of 6 nM (Ki) at the recently cloned 5-HT1F receptor. It possesses little affinity for the 56 other serotonergic and non-serotonergic neuronalContinue Reading