Lee-Peng Mok

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The biophysical properties and distribution of voltage-dependent, Ca(2+) -modulated K(+) (BK(Ca)) currents among subpopulations of acutely dissociated DiI-labeled cutaneous sensory neurons from the adult rat were characterized with whole-cell patch-clamp techniques. BK(Ca) currents were isolated from total K(+) current with iberiotoxin, charybdotoxin or(More)
BACKGROUND Inflammation-induced sensitization of primary afferents is associated with a decrease in K(+) current. However, the type of K(+) current and basis for the decrease varies as a function of target of innervation. Because glabrous skin of the rat hindpaw is used often to assess changes in nociception in models of persistent pain, the purpose of the(More)
Intracellular signaling mechanisms affected by endothelin (ET), a hypertrophic agonist, and platelet-derived growth factor (PDGF)-BB, a proliferative agonist, in vascular smooth muscle cells were examined. PDGF-BB was a potent mitogen compared with untreated cultures, stimulating both [3H]thymidine incorporation and cell number. In contrast, ET was a poor(More)
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