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Proteins of the Ena/VASP family are implicated in processes that require dynamic actin remodeling such as axon guidance and platelet activation. In this work, we explored some of the pathways that likely regulate actin dynamics in part via EVL (Ena/VASP-like protein). Two isoforms, EVL and EVL-I, were highly expressed in hematopoietic cells of thymus and(More)
Disabled gene products are important for nervous system development in drosophila and mammals. In mice, the Dab1 protein is thought to function downstream of the extracellular protein Reln during neuronal positioning. The structures of Dab proteins suggest that they mediate protein-protein or protein-membrane docking functions. Here we show that the(More)
The Abl tyrosine kinase plays an important role in axonogenesis. Recent reports indicate that this role involves interaction with several different protein families, including LAR phosphatases, catenin/cadherin cell adhesion complexes, Trio family GEFs, and Ena/VASP family actin regulatory proteins. These findings suggest that Abl and its associated(More)
The principal component of Alzheimer's amyloid plaques, Abeta, derives from proteolytic processing of the Alzheimer's amyloid protein precursor (APP). FE65 is a brain-enriched protein that binds to APP. Although several laboratories have characterized the APP-FE65 interaction in vitro, the possible relevance of this interaction to Alzheimer's disease has(More)
The synapsins are a family of neuron-specific proteins, associated with the cytoplasmic surface of synaptic vesicles, which have been shown to regulate neurotransmitter release in mature synapses and to accelerate development of the nervous system. Using neuronal cultures from mice lacking synapsin I, synapsin II, or both synapsins I and II, we have now(More)
We deduced the structure of the mouse profilin II gene. It contains five exons that can generate four different transcripts by alternative splicing. Two transcripts encode different profilin II isoforms (designated IIa and IIb) that have similar affinities for actin but different affinities for polyphosphoinositides and proline-rich sequences. Profilins IIa(More)
The expression and kinase activity of cyclin dependent kinase 5 (cdk5) parallels the extent of neuronal differentiation. Cdk5 activity has been shown to be required for neurite outgrowth, cortical lamination and the overall development of the nervous system. p35 was identified as the first regulatory activator of cdk5 whose presence is required for cdk5(More)
  • Lee Lanier
  • SIGGRAPH Computer Animation Festival
  • 2007
Sea-surface temperatures, clouds, storm tracks, and hurricane category labels are shown as the hurricane season progresses. This visualization shows some of the actual data that NASA and NOAA satellites measured in 2005 – data used to predict the paths and intensities of hurricanes. Satellite data play a vital role in helping us understand the land, ocean,(More)
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