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INTRODUCTION Shear wave elastography is a new method of obtaining quantitative tissue elasticity data during breast ultrasound examinations. The aims of this study were (1) to determine the reproducibility of shear wave elastography (2) to correlate the elasticity values of a series of solid breast masses with histological findings and (3) to compare shear(More)
BACKGROUND Tissue microarrays (TMAs) are an important tool in translational research for examining multiple cancers for molecular and protein markers. Automatic immunohistochemical (IHC) scoring of breast TMA images remains a challenging problem. METHODS A two-stage approach that involves localization of regions of invasive and in-situ carcinoma followed(More)
Tumor localization is an important component of histopathol-ogy image analysis; it has yet to be reliably automated for breast cancer histopathology. This paper investigates the use of superpixel classification to localize tumor regions. A su-perpixel representation retains information about visual structures such as cellular compartments, connective(More)
BACKGROUND Integrin αvβ6 promotes migration, invasion, and survival of cancer cells; however, the relevance and role of αvβ6 has yet to be elucidated in breast cancer. METHODS Protein expression of integrin subunit beta6 (β6) was measured in breast cancers by immunohistochemistry (n > 2000) and ITGB6 mRNA expression measured in the Molecular Taxonomy of(More)
Tissue microarrays have become an important tool in clinical research to analyse molecular and protein markers in various types of cancer. However their analysis is a time-consuming task and introduces inter-and intra-observer variations. An automated method is proposed, called spin-context, to segment in-situ and invasive tumour regions in images of breast(More)
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