Lee Gazourian

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BACKGROUND Mitochondrial DNA (mtDNA) is a critical activator of inflammation and the innate immune system. However, mtDNA level has not been tested for its role as a biomarker in the intensive care unit (ICU). We hypothesized that circulating cell-free mtDNA levels would be associated with mortality and improve risk prediction in ICU patients. METHODS AND(More)
OBJECTIVE To identify metabolomic biomarkers predictive of Intensive Care Unit (ICU) mortality in adults. RATIONALE Comprehensive metabolomic profiling of plasma at ICU admission to identify biomarkers associated with mortality has recently become feasible. METHODS We performed metabolomic profiling of plasma from 90 ICU subjects enrolled in the BWH(More)
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