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The current theory of alternating-current electro-osmosis (ACEO) is unable to explain the experimentally observed flow reversal of planar ACEO pumps at high frequency (above the peak, typically 10-100 kHz), low salt concentration (1-1000 microM) , and moderate voltage (2-6 V), even taking into account Faradaic surface reactions, nonlinear double-layer(More)
Vanilloid receptor 1 (VR1, TRPV1) is a cation-selective ion channel that is expressed on primary afferent neurons and is upregulated following inflammation and nerve damage. Blockers of this channel may have utility in the treatment of chronic nociceptive and neuropathic pain. Here, we describe the optimization from a high throughput screening hit, of a(More)
  • J. Apaéstegui, F. W. Cruz, +10 authors W. Santini
  • 2014
In this paper we explore a speleothem δ 18 O record from Palestina cave, northwestern Peru, at a site on the eastern side of the Andes cordillera, in the upper Amazon Basin. The δ 18 O record is interpreted as a proxy for South Ameri-can Summer Monsoon (SASM) intensity and allows the reconstruction of its variability during the last 1600 years. Two periods(More)
Speleothem δ 18 O and δ 13 C signals enable climate reconstructions at high resolution. However, scarce decadal and seasonally resolved speleothem records are often difficult to interpret in terms of climate due to the multitude of factors that affect the proxy signals. In this paper, a fast-growing (up to 2 mm yr −1) seasonally laminated speleothem from(More)
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