Lee Banting

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Destruxin A, a cyclohexadepsipeptide related to the enniatins and beauvericin, exhibits ionophoric properties. Calcium ion mobilization across liposomal membrane barriers, for example, has been demonstrated using the calcium ion-sensitive dyes Arsenazo III and Fura-2. Initial molecular mechanics/molecular dynamics calculations indicate the potential for(More)
A case of bovine cerebral theileriosis was confirmed at autopsy on a farm where 4 animals out of 70 died. All were less than 2 years old and all showed nervous signs. Serologically, no evidence was found of Theileria mutans or the Theileria parva group in young animals born on the farm. Six out of 13 calves 6-9 months of age were, however, serologically(More)
Copper deficiency was diagnosed in piglets from a farm in the Transvaal. The mortality rate among 5 to 8-week-old piglets had been sporadic but considerably high over a 12 month period. Affected animals showed signs of ataxia, posterior paresis, horizontal nystagmus, inability to stand and front and hind limb paddling movements. Death ensued from 3-5 days(More)
A novel molecular dynamics (MD) analysis algorithm, DASH, is introduced in this paper. DASH has been developed to utilize the sequential nature of MD simulation data. By adjusting a set of parameters, the sensitivity of DASH can be controlled, allowing molecular motions of varying magnitudes to be detected or ignored as desired, with no knowledge of the(More)
A 4.1 μs molecular dynamics simulation of the NR4A1 (hNur77) apo-protein has been undertaken and a previously undetected druggable pocket has become apparent that is located remotely from the 'traditional' nuclear receptor ligand-binding site. A NR4A1/bis-indole ligand complex at this novel site has been found to be stable over 1 μs of simulation and to(More)
Arginine-vasopressin was subjected to a long (11 μs) molecular dynamics simulation in aqueous solution. Analysis of the results by DASH and principal components analyses revealed four main ring conformations that move essentially independently of the faster-moving tail region. Two of these conformations (labeled "saddle") feature well-defined β-turns in the(More)