Lechoslaw Latos-Grazyński

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Studies of the reaction of 5-oxaporphyrin iron complexes (verdohemes) with methoxide ion or hydroxide ion have been undertaken to understand the initial step of ring opening of verdohemes. High-spin [ClFe(III)(OEOP)] undergoes a complex series of reactions upon treatment with hydroxide ion in chloroform, and similar species are also detected in(More)
Low-spin complexes of iron(III) chiroporphyrin, obtained from (1R)-cis-caronaldehyde acid methyl ester and pyrrole as the atropisomer, with R-imidazoles and cyanide have been studied by means of 1D and 2D (1)H NMR spectroscopy. A complete spectral assignment of resonances has been done on the basis of observed scalar, NOE, and EXSY correlations in 2D COSY(More)
BACKGROUND Photodynamic therapy may be a promising treatment for patients with tumors. The mechanism of its action is poorly understood and different from the cytotoxic effects induced by antitumor drugs. MATERIALS AND METHODS New sensitizers, termed as 21-selenaporphyrin (SEP) and 21-thiaporphyrin (STSP) were studied for their photocytotoxicity in vitro(More)
The main purpose of the study was to investigate the effectiveness of a new photosensitizer for photodynamic therapy. 5,20-bis(4-sulphophenyl)-10,15-bis (2-methoxy-4-sulphophenyl)-21-thiaporphyrin (21-thiaporphyrin) was compared to chlorin e6 and tetra(m-hydroxyphenyl)porphyrin (m-THPP) for its ability to sensitize tumors and skin to light. Chlorin e6 and(More)
Addition of a phenyl Grignard reagent to a toluene solution of the nickel(II) chloride complex of a dimethylated inverted porphyrin, (2-NCH3-21-CH3CTPP)NiIICl (1), at 203 K results in the formation of a rare paramagnetic (sigma-phenyl)nickel(II) species, (2-NCH3-21-CH3CTPP)NiIIPh (2). The coordination of the sigma-phenyl in 2 is determined by a unique(More)
The inverted porphyrins 2-aza-5,10,15,20-tetraphenyl-21-carbaporphyrin (CTPPH2) and its methylated derivatives 2-aza-2-methyl-5,10,15,20-tetraphenyl-21-carbaporphyrin (2-NCH3CTPPH) and 2-aza-2-methyl-5,10,15,20-tetraphenyl-21-methyl-21-carbaporphyrin (2-NCH3-21-CH3CTPPH) stabilize the rare organocopper(II) complexes (CTPP)CuII (1), (2-NCH3CTPP)CuII (2),(More)
The 5-oxaporphyrin macrocycle is a modified porphyrin (with an oxygen atom replacing a meso-methine unit) that is produced during heme degradation in biological and chemical systems. We have undertaken an investigation into the chemical reactivity of metal complexes of this macrocycle. Here we report that the diamagnetic zinc(II) and paramagnetic cobalt(II)(More)
An intermediate-spin state very close to the mid-spin state (S = 3/2) can be stabilized in a ferric porphyrin by an integrated approach which combines the favorable effects of a weak axial field strength and of a small macrocycle hole. Axial ligand exchange by reaction of chloroiron(III)tetramethylchiroporphyrin [(TMCP)FeCl] with silver perchlorate in(More)
Addition of aryl Grignard reagents [PhMgCl, PhMgBr, (Ph-d(5))MgBr, (o-MePh)MgBr, (m-MePh)MgBr] dissolved in ethyl ether or THF to toluene solutions of nickel(II) dihalide complexes of 5,10,15,20-tetraphenyl-21,23-dioxaporphyrin (O(2)TPP), 1, at 203 K resulted in formation of a variety of rare paramagnetic sigma-organonickel(II) species that have been(More)