Lech Wieczorek

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Biosensors are molecular sensors that combine a biological recognition mechanism with a physical transduction technique. They provide a new class of inexpensive, portable instrument that permit sophisticated analytical measurements to be undertaken rapidly at decentralized locations. However, the adoption of biosensors for practical applications other than(More)
2D arrays of silver semi-shells of 100 and 200 nm diameter display complex reflection and transmission spectra in the visible and near-IR. Here these spectral features are deconstructed and it is demonstrated that they result from the coupling of incident light into a delocalized Bragg plasmon, and the latter's induction of localized Mie plasmons in the(More)
The influence of film morphology on the performance of inkjet-printed gold nanoparticle chemiresistors has been investigated. Nanoparticles deposited from a single-solvent system resulted in a "coffee ring"-like structure with most of the materials deposited at the edge. It was shown that the uniformity of the film could be improved if the nanoparticles(More)
Gold nanoparticle films (Au(NPF)) functionalized with a range of hydrophobic and hydrophilic thiols were assembled in chemiresistor sensor arrays that were used to differentiate between complex mixtures of analytes in the aqueous phase. A chemiresistor array sampled a simple system of linear alcohols (methanol, ethanol, propan-1-ol, and butan-1-ol)(More)
The electrical resistance of nanoparticle assemblies in the form of thin films shows semiconductor-like behavior at low temperatures and metal-like behaviour at high temperatures. We show that this resistance behavior is due to the interplay between Coulomb blockade reduced tunneling of electrons between nanoparticles and the thermal expansion of the(More)
Partially selective gold nanoparticle sensors have the sensitivity and selectivity to discriminate and quantify benzene, toluene, ethylbenzene, p-xylene and naphthalene (BTEXN) at concentrations relevant to the US Environmental Protection Agency. In this paper we demonstrate that gold nanoparticle chemiresistors can do so in the presence of 16 other(More)
The ability to express and purify modified recombinant signalling proteins such that they retain their biological function in a cell-free context has provided a basis for production of molecular biosensors. Here the authors utilise G-protein coupled receptors (GPCRs) and their G-proteins to detect various binding partners in a cell-free environment.(More)
A biosensor technology is described which provides a direct measurement for functional molecular interactions, at the surface of a tethered bilayer membrane, through the electrical transduction of chemically modified ion-channels. High sensitivity of analyte detection is achieved due to the large flux of ions transmitted through the ion channel. The(More)
An immunosensing device, comprising a lipid membrane incorporating ion channels tethered to the surface of a gold electrode, has been reported [Cornell, Braach-Maksvytis, King, Osman, Raguse, Wieczorek and Pace (1997) Nature (London) 387, 580-583]. The present article describes key steps in the assembly of the device and provides further evidence for its(More)