Lech Sedlak

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BACKGROUND The methods used in treatment of osteoporosis induced by glucocorticosteroids are not effective enough. There is a need for new drugs which could be useful in counteracting the influence of glucocorticosteroids on osseous tissue. The aim of the present study was to investigate the effects of thalidomide on the development of osteoporosis induced(More)
INTRODUCTION Imatinib mesylate (IM) remains the treatment of choice for chronic myeloid leukemia (CML) showing a remarkable efficacy and offers a perspective for long disease-free survival. Due to prolonged administration of IM, the questions about the possible impact on the development of secondary malignancies (SM) are raised. OBJECTIVE To investigate(More)
It has been established that sows up- or down-regulate their milk production as the frequency of nursings is changed. The amount of udder massage by piglets might also influence milk production. To investigate whether these effects are associated with changes in prolactin or insulin levels, we enforced five sows each to nurse either every 35 min (MIN35) or(More)
OBJECTIVES We evaluated the safety and outcome of allo-HSCTs in myelofibrosis (MF). METHODS A total of 27 patients with primary (n = 20) or secondary (n = 7) MF, aged 51 (21-63) yr, transplanted from HLA-matched related (59%) or unrelated (41%) donors were analyzed. Conditioning was reduced in 26 and myeloablative in one patient; and ATG was used in 25.(More)
Thalidomide has indications for the treatment of several immune-related, neoplastic, and inflammatory diseases, in both adults and children. Despite numerous therapeutic indications for the application of thalidomide, the influence of that drug upon skeletal system has not been recognized. The aim of the present study was to investigate the effects of(More)
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