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The P2X7 receptor channel: recent developments and the use of P2X7 antagonists in models of disease.
- Rachael Bartlett, Leanne Stokes, Ronald Sluyter
- Pharmacological reviews
- 2014
The P2X7 receptor is a trimeric ATP-gated cation channel found predominantly, but not exclusively, on immune cells. P2X7 activation results in a number of downstream events, including the release of… (More)
- Leanne Stokes, Stephen J. Fuller, Ronald Sluyter, Kristen K. Skarratt, Ben J Gu, James S. Wiley
- FASEB journal : official publication of the…
- 2010
The P2X(7) receptor is an ATP-gated cation channel expressed in immune cells and plays a role in proinflammatory cytokine release from monocytes and macrophages. This study investigated the… (More)
- Ronald Sluyter, Leanne Stokes
- Recent patents on DNA & gene sequences
- 2011
The human P2X7 receptor is a trimeric ligand-gated cation channel coded by the P2XR7 gene located at chromosome position 12q24. P2X7 is expressed in a wide variety of normal and disease-associated… (More)
- Kathryn Vaughan, Leanne Stokes, +7 authors Moira K B Whyte
- Journal of immunology
- 2007
Neutrophils undergo rapid constitutive apoptosis that is delayed by a range of pathogen- and host-derived inflammatory mediators. We have investigated the ability of the nucleotide ATP, to which… (More)
- Leanne Stokes, Li-he Jiang, +10 authors Annmarie Surprenant
- British journal of pharmacology
- 2006
BACKGROUND AND PURPOSE
The ATP-gated P2X(7) receptor has been shown to play a role in several inflammatory processes, making it an attractive target for anti-inflammatory drug discovery. We have… (More)
- James S. Wiley, Ronald Sluyter, Ben J Gu, Leanne Stokes, Stephanie J. Fuller
- Tissue antigens
- 2011
The human P2X7 receptor is a two-transmembrane ionotropic receptor which has a ubiquitous distribution and is most highly expressed on immune cells. In macrophages and similar myeloid cells primed by… (More)
- Stephen J. Fuller, Leanne Stokes, Kristen K. Skarratt, Ben J Gu, James S. Wiley
- Purinergic Signalling
- 2009
The P2RX7 gene is highly polymorphic, and many single nucleotide polymorphisms (SNPs) underlie the wide variation observed in P2X7 receptor responses. We review the discovery of those non-synonymous… (More)
- Leanne Stokes, Katrina J. Scurrah, +5 authors James S. Wiley
- Hypertension
- 2011
The P2X4 receptor is involved in endothelium-dependent changes in large arterial tone in response to shear stress and is, therefore, potentially relevant to arterial compliance and pulse pressure.… (More)
- Niklas Rye Jørgensen, Lise Bjerre Husted, +12 authors James S. Wiley
- European Journal of Human Genetics
- 2012
The purinergic P2X7 receptor has a major role in the regulation of osteoblast and osteoclast activity and changes in receptor function may therefore affect bone mass in vivo. The aim of this study… (More)
- Leanne Stokes, Annmarie Surprenant
- European journal of immunology
- 2009
ATP-gated P2X(4) receptors (P2X(4)R) in macrophages and microglia have been implicated in neuropathic and inflammatory pain by currently unidentified mechanisms. P2X(4)R are found predominantly in… (More)