Leandro Oliveira Bortot

Learn More
The protein structure prediction problem continues to elude scientists. Despite the introduction of many methods, only modest gains were made over the last decade for certain classes of prediction targets. To address this challenge, a social-media based worldwide collaborative effort, named WeFold, was undertaken by 13 labs. During the collaboration, the(More)
The present study deals with the EEG (electroencephalogram) and behavioural effects of a subconvulsant dose (30 mg/kg i.p.) of pentylenetetrazole in freely moving rats pretreated (100 mg/kg p.o., 1 h before pentylenetetrazole) with two classic (theophylline and caffeine) and two new (enprofylline and isbufylline) xanthines. In rats treated with vehicle,(More)
The Protein Structure Prediction (PSP) problem is concerned about the prediction of the native tertiary structure of a protein in respect to its amino acids sequence. PSP is a challenging and computationally open problem. Therefore, several researches and methodologies have been developed for it. In this way, developers are working to integrate frameworks(More)
Changes in the concentration of different ions modulate several cellular processes, such as Ca2+ and Zn2+ in inflammation. Upon activation of immune system effector cells, the intracellular Ca2+ concentration rises propagating the activation signal, leading to degranulation and generation of reactive oxygen species, which increases the Zn2+ intracellular(More)
  • 1