Leah Ogier

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Correct orientation of the mitotic spindle in stem cells underlies organogenesis. Spindle abnormalities correlate with cancer progression in germ line-derived tumors. We discover a macromolecular complex between the scaffolding protein Gravin/AKAP12 and the mitotic kinases, Aurora A and Plk1, that is down regulated in human seminoma. Depletion of Gravin(More)
Filtration through the kidney eliminates toxins, manages electrolyte balance, and controls water homeostasis. Reabsorption of water from the luminal fluid of the nephron occurs through aquaporin-2 (AQP2) water pores in principal cells that line the kidney-collecting duct. This vital process is impeded by formation of an "actin barrier" that obstructs the(More)
stem cells A mitotic kinase scaffold depleted in testicular seminomas impacts spindle orientation in germline Fernando Santana, Linda Wordeman, John D Scott Heidi Hehnly, David Canton, Paula Bucko, Lorene K Langeberg, Leah Ogier, Irwin Gelman, L http://dx.doi.org/10.7554/eLife.09384 DOI: Cite as: eLife 2015;10.7554/eLife.09384 Published: 25 September 2015(More)
18 Running Title: A mitotic kinase scaffold impacts spindle orientation 19 20 ABSTRACT 24 25 Correct orientation of the mitotic spindle in stem cells underlies organogenesis. 26 Spindle abnormalities correlate with cancer progression in germline-derived 27 tumors. We discover a macromolecular complex between the scaffolding protein 28 Gravin/AKAP12 and the(More)
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