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  • Leah M. Hesse, Karthik Venkatakrishnan, +4 authors David J Greenblatt
  • Chemistry, Medicine
  • Drug metabolism and disposition: the biological…
  • 2000 (First Publication: 1 October 2000)
  • The in vitro biotransformation of bupropion to hydroxybupropion was studied in human liver microsomes and microsomes containing heterologously expressed human cytochromes P450 (CYP). The meanExpand
  • Michael H. Court, Xiuling Zhang, Xinxin Ding, Karen K. Yee, Leah M. Hesse, Moshe Finel
  • Biology, Medicine
  • Xenobiotica; the fate of foreign compounds in…
  • 2012 (First Publication: 29 January 2012)
  • The purpose of this study was to generate, by real-time PCR, a quantitative expression level profile of the 19 human UDP-glucuronosyltransferases (UGTs) of subfamilies 1A, 2A and 2B, in 26 adult andExpand
  • Leah M. Hesse, Lisa L. von Moltke, Richard I. Shader, David J Greenblatt
  • Chemistry, Medicine
  • Drug metabolism and disposition: the biological…
  • 2001 (First Publication: 1 February 2001)
  • Since antiretroviral drugs are known to inhibit many cytochrome P450 isoforms, the inhibition of CYP2B6 by non-nucleoside reverse transcriptase inhibitors and viral protease inhibitors was studied inExpand
  • Soundararajan Krishnaswamy, Qin Hao, +4 authors Michael H. Court
  • Chemistry, Medicine
  • Journal of Pharmacology and Experimental…
  • 2005 (First Publication: 1 June 2005)
  • The objective of this study was to use recombinant enzymes and human liver microsomes (HLMs) to comprehensively evaluate the functional impact of the three most common nonsynonymous polymorphismsExpand
  • Michael H. Court, Su Xiang Duan, Leah M. Hesse, Karthik Venkatakrishnan, David J Greenblatt
  • Medicine
  • Anesthesiology
  • 2001 (First Publication: 1 January 2001)
  • BackgroundOxidation of propofol to 4-hydroxypropofol represents a significant pathway in the metabolism of this anesthetic agent in humans. The aim of this study was to identify the principalExpand
  • Soundararajan Krishnaswamy, Qin Hao, +4 authors Michael H. Court
  • Medicine, Biology
  • Journal of Pharmacology and Experimental…
  • 2005 (First Publication: 1 June 2005)
  • UDP glucuronosyltransferase (UGT) 1A6 is a major isoform in human liver that glucuronidates numerous drugs, toxins, and endogenous substrates with high interindividual variability. The molecularExpand