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Although a large prospective study of fever in returning travellers has recently been published by researchers at the Hospital for Tropical Diseases in London, the patients in that study were highly selected and did not include children. To our knowledge this is the first prospective study of fever in children in the United Kingdom who have recently spent(More)
BACKGROUND Genetics and environmental conditions early in life are known to influence height. However, evidence is restricted to studies conducted at a specific age, and thus the effect on the entire growth trajectory has been neglected. OBJECTIVE The objective was to determine when parental height and factors early in offspring life start to affect(More)
Two approaches commonly used to deal with missing data are multiple imputation (MI) and inverse-probability weighting (IPW). IPW is also used to adjust for unequal sampling fractions. MI is generally more efficient than IPW but more complex. Whereas IPW requires only a model for the probability that an individual has complete data (a univariate outcome), MI(More)
BACKGROUND The contribution of body mass index (BMI) at different life stages to adult blood pressure (BP) is not well known. We investigated whether changes in BMI across childhood and adulthood, and birthweight, influence BP in mid-adulthood. METHODS AND RESULTS In 9297 participants in the 1958 British birth cohort, we analysed BMI measures at several(More)
OBJECTIVES This study examined predictors of low back pain onset in a British birth cohort. METHODS Univariate and multivariate analyses focused on individuals who experienced onset of low back pain at 32 to 33 years of age (n= 571) and individuals who were pain free (n = 5210). Participants were members of the 1958 British birth cohort. RESULTS(More)
BACKGROUND Cortisol levels may be altered in childhood in association with maltreatment (neglect, abuse and witnessing abuse) and other adversities, yet little is known about whether effects on cortisol persist into later life. AIMS To establish whether childhood psychosocial adversities predict cortisol levels in mid-adulthood. METHOD Childhood(More)
The influence of adversity over long periods of the life-span on adult cortisol metabolism is not established. We assess whether morning cortisol levels are associated with socio-economic position (SEP) from birth to mid-adulthood, and if so, whether the association is due primarily to SEP in childhood, adulthood or both. Data are from 6335 participants in(More)
BACKGROUND/AIMS Parent-offspring adiposity associations are well-established: offspring of obese parents have elevated risks of overweight/obesity. The aim of studies based on the 1958 British birth cohort has been to gain insights into explanations of these associations, such as whether parent-offspring BMI associations are due to offspring lifestyles or(More)
OBJECTIVES Short leg length has been associated with increased disease risk. We investigated (1) whether taller childhood stature predicts longer adult leg than trunk length; (2) the effects of early life factors on adult leg/trunk length. METHODS We used data from the 1958 British birth cohort on height in childhood and at 45 years, leg and trunk length(More)
CONTEXT Early growth and obesity are associated with adult chronic disease. A suspected mediator is the hypothalamic-pituitary-adrenal axis and cortisol regulation. Our prior hypothesis was that cortisol levels are affected by anthropometry at several life stages. OBJECTIVE The objective of the study was to assess whether prenatal and postnatal growth and(More)