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The incoherent feedforward loop can provide fold-change detection in gene regulation.
Many sensory systems (e.g., vision and hearing) show a response that is proportional to the fold-change in the stimulus relative to the background, a feature related to Weber's Law. RecentExpand
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Evidence that fold-change, and not absolute level, of beta-catenin dictates Wnt signaling.
In response to Wnt stimulation, beta-catenin accumulates and activates target genes. Using modeling and experimental analysis, we found that the level of beta-catenin is sensitive to perturbations inExpand
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Fold-change detection and scalar symmetry of sensory input fields
Recent studies suggest that certain cellular sensory systems display fold-change detection (FCD): a response whose entire shape, including amplitude and duration, depends only on fold changes inExpand
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Self-repairing symmetry in jellyfish through mechanically driven reorganization
Significance Animals are endowed with the capacity to repair injuries. In this study, we found that, upon amputation, the moon jellyfish Aurelia aurita rearranges existing body parts and recoversExpand
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The Jellyfish Cassiopea Exhibits a Sleep-like State
Do all animals sleep? Sleep has been observed in many vertebrates, and there is a growing body of evidence for sleep-like states in arthropods and nematodes [1-5]. Here we show that sleep is alsoExpand
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Allosteric proteins as logarithmic sensors
Significance Biological sensory systems have the capacity to respond to signals over a broad range of intensities, be it vision in animals or signal transduction in cells. Such a broad response rangeExpand
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Sensing relative signal in the Tgf-β/Smad pathway
Significance It is not fully understood how cells process information in the face of noise. We posed this question in the transforming growth factor-β (Tgf-β) pathway, a major intercellular signalingExpand
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Self-repairing symmetry in jellyfish
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Two-Element Transcriptional Regulation in the Canonical Wnt Pathway
The canonical Wnt pathway regulates numerous fundamental processes throughout development and adult physiology and is often disrupted in diseases [1-4]. Signal in the pathway is transduced byExpand
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Signaling pathways as linear transmitters
One challenge in biology is to make sense of the complexity of biological networks. A good system to approach this is signaling pathways, whose well-characterized molecular details allow us to relateExpand
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