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BACKGROUND The flow-rate limiting and directional characteristics of caudally directed microcatheters, which lead to intrathecal maldistribution of hyperbaric 5% lidocaine, are believed to have contributed to at least 11 cases of cauda equina syndrome. The authors investigated the distribution characteristics of hyperbaric dye solutions via caudally(More)
To evaluate the influence of exercise on the apolipoprotein (apo) composition of very low density lipoprotein (VLDL) subfractions, we exercised 6 sedentary men for 30 min, 1 h after a fatty meal. VLDL fractions from samples drawn 4, 6 and 8 h post-prandially were separated from pre-stained plasma by high performance liquid chromatography and fractionated to(More)
The weanling rat, an animal model of rapid bone turnover, was used to evaluate the effects of various doses of cyclosporin A (CsA) on various bones during different time periods. Sprague-Dawley male rats were extensively prelabeled with 3H-tetracycline during 1–3 weeks of age. At 4 weeks of age, four groups of rats were given daily subcutaneous injections:(More)
This study compares absolute rates of bone resorption and formation at the organ level in adolescent Sprague-Dawley rats as a function of sex and type of bone. Bone r’esorption and formation were quantified in rapidly growing male and female rats (4-7 weeks of age) who were multiply prelabeled with [3H]tetracycline. Ten different whole bones were compared:(More)
Bone resorption and formation in terms of milligram of calcium deposited into and released from whole humerus of 15–23 weeks old male rats were assessed, via linear least-squares regression analysis of change in calcium content and3H-tetracycline kinetics of the bone. The rate of resorption was 0.376 mg calcium per day, while formation was 0.758 mg calcium(More)
Grapefruit juice can modify the pharmacokinetic parameters of many drugs, in particular simvastatin, an orally active cholesterol-lowering agent. The exact components in grapefruit juice responsible for drug interactions are not perfectly known. However, it seems that bergamottin, a furocoumarin derivative, is one of the main active components within(More)
The aim of this paper is to describe a new methodology for the separation of human high-density lipoproteins (HDL) into apolipoprotein (apo) E-poor and apo E-rich subfractions by fast protein liquid chromatography (FPLC) using a heparin affinity column. Recoveries for apolipoproteins AI, AII, CI, CII, CIII, and E were 68.9, 74.7, 71.9, 73.5, 40.0, and(More)
Microphthalmic mice and their normal littermates were prelabeled extensivelyin utero with3H-tetracycline and3H-proline, or with45Ca alone. The loss of3H-tetracycline and3H-collagen from whole femur was measured from birth to 24 days of age at weekly intervals to determine bone resorption of mineral and matrixin vivo. The ratio of blood45Ca specific activity(More)
Fig. 6. Relationship between cortical BMD and relative cortical volume in a 2.5 mm-thick section at a distance of 15% from the distal end of the radius in females. A highly significant correlation was obtained between cortical BMD and relative cortical volume with r 2 = 0.813, P < 0.001. Note almost identical slopes in males and females. The maximum density(More)
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