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During protein synthesis, the ribosome controls the movement of tRNA and mRNA by means of large-scale structural rearrangements. We describe structures of the intact bacterial ribosome from Escherichia coli that reveal how the ribosome binds tRNA in two functionally distinct states, determined to a resolution of ~3.2 angstroms by means of x-ray(More)
In bacteria, the translocation of tRNA and mRNA with respect to the ribosome is catalyzed by the conserved GTPase elongation factor-G (EF-G). To probe the rate-determining features in this process, we imaged EF-G-catalyzed translocation from two unique structural perspectives using single-molecule fluorescence resonance energy transfer. The data reveal that(More)
of two influenza A viruses from a pilot whale. et al. Mass mortality of harbor seals: pneumonia associated with influenza A virus. Pathogen exposure and blood chemistry in the Washington, USA population of northern sea otters (Enhydra lutris kenyoni). pathogen exposure and general health status of live and beach-cast Washington sea otters (Enhydra lutris(More)
In Ohio, United States, in early 2014, a deltacoronavirus was detected in feces and intestine samples from pigs with diarrheal disease. The complete genome sequence and phylogenetic analysis of the virus confirmed that the virus is closely related to a porcine deltacoronavirus (porcine coronavirus HKU15) reported in Hong Kong in 2012.
To the Editor: Porcine corona-virus (PorCoV) HKU15 is a single-stranded, positive-sense, enveloped RNA virus belonging to the genus Deltacoronavirus (family Coronaviri-dae). PorCoV HKU15 was first identified in 2012 in a surveillance study from China (1). Until February 2014, however, the role of this virus strain in clinical diseases of pigs had not been(More)
Accurate estimation of the state of charge (SOC) of batteries is one of the key problems in a battery management system. This paper proposes an adaptive SOC estimation method based on unscented Kalman filter algorithms for lithium (Li)-ion batteries. First, an enhanced battery model is proposed to include the impacts due to different discharge rates and(More)
Influenza-like illnesses (ILI), a subset of acute respiratory infections (ARI), are a significant source of morbidity and mortality worldwide. ILI can be caused by numerous pathogens, however; there is limited information on the etiology and epidemiology of ILI in China. We performed a one-year surveillance study (2010) of viral etiology causing ILI and(More)
Norovirus (NoV) P domain complexes, the 24 mer P particles and the P dimers, induced effective humoral immunity, but their role in the cellular immune responses remained unclear. We reported here a study on cellular immune responses of the two P domain complexes in comparison with the virus-like particle (VLP) of a GII.4 NoV (VA387) in mice. The P domain(More)
SUMMARY Control of aftertreatment systems for lean burn technology engines represents a big challenge, due to the lack of on-board emission measurements and the sensitivity of the hardware components to ageing and sulphur poisoning. In this paper, we consider the control and adaptation of aftertreatment systems involving lean NO x trap (LNT). A(More)
First identified in 2012 in a surveillance study in Hong Kong, porcine deltacoronavirus (PDCoV) is a proposed member of the genus Deltacoronavirus of the family Coronaviridae. In February of 2014, PDCoV was detected in pigs with clinical diarrheal symptoms for the first time in the USA. Since then, it has been detected in more than 20 states in the USA and(More)