Le Wu

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BACKGROUND Neural damage can be mitigated by calcium-channel blockers (CCBs). However, the mechanism of action of CCBs is not yet fully understood. Objective : To investigate the mechanism of action and efficacy of CCB, flunarizine in restoring neural function after crush injury to the nerves. MATERIALS AND METHODS The sciatic nerves of rats were crushed(More)
The modulatory effects of methionine-enkephalin (M-ENK) and selective opioid-receptor agonists on GABA-activated whole-cell currents were investigated in neurons acutely dissociated from the superficial laminae of the rat spinal dorsal horn using nystatin-perforated patch recording configuration under voltage-clamp conditions. The results show that: (1).(More)
OBJECTIVES Lipoxin A4 (LXA4) is a potent anti-inflammatory mediator that exerts a neuroprotective effect following cerebral ischaemia/reperfusion (I/R) injury. However, little is known about the underlying mechanisms. Upregulation of nuclear factor erythroid 2-related factor 2 (Nrf2) is generally considered to reduce cerebral I/R injury. Nuclear factor(More)
Collaborative Filtering(CF) is a popular way to build recommender systems and has been successfully employed in many applications. Generally, two kinds of approaches to CF, the <i>local</i> neighborhood methods and the <i>global</i> matrix factorization models, have been widely studied. Though some previous researches target on combining the complementary(More)
The problem of multi-label classification has attracted great interests in the last decade. Multi-label classification refers to the problems where an example that is represented by a single instance can be assigned to more than one category. Until now, most of the researches on multi-label classification have focused on supervised settings whose assumption(More)
Lipoxin A4 (LXA4), a biologically active eicosanoid with anti-inflammatory and pro-resolution properties, was recently found to have neuroprotective effects in brain ischemia. As 5-lipoxygenase (5-LOX) and leukotrienes are generally considered to aggravate cerebral ischemia/reperfusion (I/R) injury, we investigated their effects on LXA4-mediated(More)
BACKGROUND Vasoactive drug alprostadil improves microcirculation and can be effective in treating disorders of peripheral nerves. Vascular endothelial growth factor (VEGF) has been shown to have protective action in cerebral ischemia, disorders of spinal cord, and also peripheral nerves. However, the mechanism of action of VEGF in peripheral nerve injuries(More)
—P2P lending is an online platform to make borrowing and investment transactions. A central question on these platforms is how to align the right products with the right investors, thus helping investors to make better decisions. Along this line, tremendous efforts have been devoted to modeling the credits of products and borrowers from an economic(More)
The modulatory effect of adenosine on gamma-aminobutyric acid (GABA)-activated whole-cell currents were investigated in the neurons acutely dissociated from the rat sacral dorsal commissural nucleus (SDCN) using the nystatin perforated patch recording configuration under the voltage-clamp conditions. The results showed that: (1) GABA acted on GABAA receptor(More)