Lawrence S. Mok

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This paper gives an overview of the BlueGene/L Supercomputer. This is a jointly funded research partnership between IBM and the Lawrence Livermore National Laboratory as part of the United States Department of Energy ASCI Advanced Architecture Research Program. Application performance and scaling studies have recently been initiated with partners at a(More)
As 1999 ended, IBM announced its intention to construct a one-petaflop supercomputer. The construction of this system was based on a cellular architecture—the use of relatively small but powerful building blocks used together in sufficient quantities to construct large systems. The first step on the road to a petaflop machine (one quadrillion floating-point(More)
Bats are a major reservoir of emerging infectious viruses. Many of these viruses are highly pathogenic to humans however bats remain asymptomatic. The mechanism by which bats control viral replication is unknown. Here we utilize an integrated approach of proteomics informed by transcriptomics to compare the response of immortalized bat and human cells(More)
Large powerful networks coupled to state-of-the-art processors have traditionally dominated supercomputing. As technology advances, this approach is likely to be challenged by a more cost-effective System-On-A-Chip approach, with higher levels of system integration. The scalability of applications to architectures with tens to hundreds of thousands of(More)
Bats are recognised as an important reservoir for a number of highly pathogenic zoonotic viruses. While many of these viruses cause severe and often fatal disease in humans, bats are able to coexist with these viruses without clinical signs of disease. The mechanism conferring this antiviral response is not fully understood. Here, we investigated the(More)
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