Lawrence S. Mok

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Blue Gene/L supercomputer P. Coteus H. R. Bickford T. M. Cipolla P. G. Crumley A. Gara S. A. Hall G. V. Kopcsay A. P. Lanzetta L. S. Mok R. Rand R. Swetz T. Takken P. La Rocca C. Marroquin P. R. Germann M. J. Jeanson As 1999 ended, IBM announced its intention to construct a onepetaflop supercomputer. The construction of this system was based on a cellular(More)
This paper gives an overview of the BlueGene/L Supercomputer. This is a jointly funded research partnership between IBM and the Lawrence Livermore National Laboratory as part of the United States Department of Energy ASCI Advanced Architecture Research Program. Application performance and scaling studies have recently been initiated with partners at a(More)
Normal cell polarity protects epithelial cells against Pseudomonas aeruginosa invasion and cytotoxicity. Using epithelial cell clones with selective defects in sorting of membrane constituents, and using hepatocyte growth factor pretreatment, we found that polarized susceptibility to P. aeruginosa can be altered without disrupting tight junctions. The(More)
Bats are a major reservoir of emerging infectious viruses. Many of these viruses are highly pathogenic to humans however bats remain asymptomatic. The mechanism by which bats control viral replication is unknown. Here we utilize an integrated approach of proteomics informed by transcriptomics to compare the response of immortalized bat and human cells(More)
Bats harbor many emerging and reemerging viruses, several of which are highly pathogenic in other mammals but cause no clinical signs of disease in bats. To determine the role of interferons (IFNs) in the ability of bats to coexist with viruses, we sequenced the type I IFN locus of the Australian black flying fox, Pteropus alecto, providing what is, to our(More)
Bats are recognised as an important reservoir for a number of highly pathogenic zoonotic viruses. While many of these viruses cause severe and often fatal disease in humans, bats are able to coexist with these viruses without clinical signs of disease. The mechanism conferring this antiviral response is not fully understood. Here, we investigated the(More)
In recent years, bats have been identified as a natural reservoir for a diverse range of viruses. Nelson Bay orthoreovirus (NBV) was first isolated from the heart blood of a fruit bat (Pteropus poliocephalus) in 1968. While the pathogenesis of NBV remains unknown, other related members of this group have caused acute respiratory disease in humans. Thus the(More)
Large powerful networks coupled to state-of-the-art processors have traditionally dominated supercomputing. As technology advances, this approach is likely to be challenged by a more cost-effective System-On-A-Chip approach, with higher levels of system integration. The scalability of applications to architectures with tens to hundreds of thousands of(More)
Nelson Bay orthoreovirus (NBV) is a fusogenic bat borne virus with an unknown zoonotic potential. Previous studies have shown that NBV can infect and replicate in a wide variety of cell types derived from their natural host (bat), as well as from human, mouse and monkey. Within permissive cells, NBV induced significant cytopathic effects characterised by(More)
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