Lawrence Plon

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The antidepressant properties of S-adenosylmethionine, an endogenous methyl donor, were studied in inpatients who met the DSM-III criteria for major depression. Nine patients given intravenous S-adenosylmethionine and nine given low oral doses of imipramine were compared in a double-blind design for 14 days. The S-adenosylmethionine produced superior(More)
Twelve patients with schizophrenia received positron emission tomography scans with 18F-deoxyglucose before and after 4 to 6 weeks of treatment with clozapine or thiothixene. Both stereotaxic and magnetic resonance image template methods were used to position regions of interest for metabolic rate analysis. Clozapine increased and thiothixene decreased(More)
INTRODUCTION The relationship between plasma levels of S-adenosylmethionine (SAMe), an endogenous methyl donor, and clinical response were studied in patients with a DSM-III-R diagnosis of major depression. MATERIAL AND METHODS A double-blind randomized protocol comparing oral SAMe with oral desipramine, involving a total of 26 patients, was employed. (More)
BACKGROUND Little is known about longitudinal prescribing practices for psychoactive medications for individuals with intellectual disabilities and developmental disabilities (IDDD) who are living in community settings. METHODS Computerized pharmacy records were accessed for 2344 community-based individuals with IDDD for whom a total of 3421 prescriptions(More)
Studies have suggested that consciousness is encoded discretely in time and synchronously in space of the brain. The present study was to model the alpha EEG as a brain clock to carry out the functions and to test whether the quality and rate of the oscillation could predict behavioral timing. Results showed that the alpha peak frequency was correlated with(More)
BACKGROUND AND PURPOSE Animal data suggest the use of beta-human chorionic gonadotropin followed by erythropoietin to promote brain repair after stroke. The current study directly translated these results by evaluating safety of this sequential growth factor therapy through a 3-center, single-dose, open-label, noncontrolled, Phase IIa trial. METHODS(More)
The advent of improved diagnostic criteria, coupled with a refined psychotropic armamentarium, can now produce rapid clinical improvements in clinical psychiatric conditions for which both patients and therapist may be unprepared. The following case report illustrates this problem which will become increasingly important in the practice of psychiatry as(More)