Lawrence P. Chong

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AIMS To evaluate the effect of switching to bevacizumab or ranibizumab after developing tachyphylaxis during anti-vascular endothelial growth factor (VEGF) therapy for choroidal neovascularisation (CNV). METHODS The authors reviewed the records of all patients who received both ranibizumab and bevacizumab for treatment of CNV to identify those who(More)
PURPOSE To evaluate the safety and efficacy of 25-gauge instrumentation for a variety of vitreoretinal conditions on previously nonvitrectomized eyes. DESIGN Single-center, retrospective, interventional case series. PARTICIPANTS One-hundred forty eyes of 140 patients were evaluated at the Doheny Retina Institute from July 2002 to July 2003. (More)
PURPOSE To evaluate porcine vitreous flow and balanced saline solution (BSS) flow rates in different vitrectomy systems. METHODS Porcine vitreous was obtained within 24 hours of slaughter. A high-speed (2 samples/s) balance, precise to 0.01 g, was used. Variable cut rates and vacuum pressures were analyzed in vitreous and BSS. The vitreous was labeled(More)
The objective of the present study was to test the hypothesis that the fracture strength of calcium hydroxide and mineral trioxide aggregate (MTA)-filled immature teeth decreased over time. Immature mandibular incisors from sheep were extracted and the pulps were extirpated using an apical approach with a barbed broach, and the teeth were divided into three(More)
OBJECTIVE To evaluate the efficacy of the ganciclovir implant in the treatment of recurrent cytomegalovirus (CMV) retinitis. METHODS Patients with acquired immunodeficiency syndrome and recurrent CMV retinitis were evaluated for entry into the study. A ganciclovir implant was inserted in 91 eyes of 70 patients between October 1992 and October 1995. The(More)
PURPOSE To quantify the vitreous traction created by pneumatic (20-, 23-, and 25-gauge) and electric cutters (20- and 25-gauge) during vitrectomy. DESIGN Experimental study. PARTICIPANTS This is a preclinical study, and no patients were involved. METHODS Five separate cutters for each drive mechanism and gauge (20-, 23-, and 25-gauge pneumatic and 20-(More)
We did a retrospective review of the consecutive vitrectomies for traction retinal detachment associated with retinopathy of prematurity performed at our institution. Fifty-eight eyes were operated on in 46 patients at less than 1 year of age, including 12 eyes with partial retinal detachments and 46 eyes with total retinal detachments. Only patients with(More)
A clinicopathologic report of late-onset bacterial endophthalmitis 4 years after implantation of a Baerveldt drainage implant is described. An 80-year-old woman with glaucoma presented 8 years after tube shunt implantation with clinical endophthalmitis. During surgical removal of the implant, a small conjunctival buttonhole caused by the suture securing the(More)
Subretinal neovascular membranes cause late visual loss and are important determinants of final visual acuity in patients with Vogt-Koyanagi-Harada syndrome. The purpose of this study was to determine the prevalence and risk factors associated with the development of subretinal neovascular membranes in Vogt-Koyanagi-Harada syndrome. We reviewed the charts(More)
Pneumocystis carinii pneumonia is a major cause of morbidity and mortality in patients with the acquired immunodeficiency syndrome. When P. carinii is disseminated, the choroid may be involved and the infection is often fatal. We examined, treated, and followed up two patients who developed choroidal lesions typical of P. carinii while taking aerosolized(More)