Lawrence Keen

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Despite the enormous therapeutic potential of siRNA as a treatment strategy, the delivery is still a problem due to unfavorable biodistribution profiles and poor intracellular bioavailability. Calcium phosphate (CaP) co-precipitate has been used for nearly 40 years for in vitro transfection due to its non-toxic nature and simplicity of preparation. The(More)
Insect glial cells derived from the embryonic brain of Periplaneta americana cockroaches have been kept in primary culture conditions for up to 3 weeks. Under the culture conditions used, the glial cells differentiated and formed a complex cellular network on the floor of the culture vessels from which glial-glial and glial-neuronal contacts could be seen.(More)
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