Lawrence J. Mandarino

Dawn K. Coletta8
Gabriel Q. Shaibi6
8Dawn K. Coletta
6Gabriel Q. Shaibi
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  • Kristen E. Boyle, Hyonson Hwang, Rachel C. Janssen, James M. DeVente, Linda A. Barbour, Teri L. Hernandez +3 others
  • 2014
The rising prevalence of gestational diabetes mellitus (GDM) affects up to 18% of pregnant women with immediate and long-term metabolic consequences for both mother and infant. Abnormal glucose uptake and lipid oxidation are hallmark features of GDM prompting us to use an exploratory proteomics approach to investigate the cellular mechanisms underlying(More)
  • Hyonson Hwang, Benjamin P. Bowen, Natalie Lefort, Charles R. Flynn, Elena A. De Filippis, Christine Roberts +5 others
  • 2010
OBJECTIVE Insulin resistance in skeletal muscle is an early phenomenon in the pathogenesis of type 2 diabetes. Studies of insulin resistance usually are highly focused. However, approaches that give a more global picture of abnormalities in insulin resistance are useful in pointing out new directions for research. In previous studies, gene expression(More)
This study was undertaken to test the hypothesis that short-term exposure (4 h) to physiological hyperinsulinemia in normal, healthy subjects without a family history of diabetes would induce a low grade inflammatory response independently of glycemic status. Twelve normal glucose tolerant subjects received a 4-h euglycemic hyperinsulinemic clamp with(More)
OBJECTIVE In adults, the shape of the glucose response during an oral glucose tolerance test (OGTT) prospectively and independently predicts type 2 diabetes. However, no reports have described the utility of this indicator in younger populations. The purpose of this study was to compare type 2 diabetes risk factors in Latino adolescents characterized by(More)
  • Carrie S. McLean, Clinton Mielke, Jeanine M. Cordova, Paul R. Langlais, Benjamin Bowen, Danielle Miranda +2 others
  • 2015
BACKGROUND Healthy individuals on the lower end of the insulin sensitivity spectrum also have a reduced gene expression response to exercise for specific genes. The goal of this study was to determine the relationship between insulin sensitivity and exercise-induced gene expression in an unbiased, global manner. METHODS AND FINDINGS Euglycemic clamps were(More)
OBJECTIVE Lifestyle intervention can improve insulin sensitivity in obese youth, yet few studies have examined the molecular signatures associated with these improvements. Therefore, the purpose of this study was to explore gene expression changes in whole blood that are associated with intervention-induced improvements in insulin sensitivity. METHODS(More)
MOTIVATION Modern techniques have produced many sequence annotation databases and protein structure portals, but these Web resources are rarely integrated in ways that permit straightforward exploration of protein functional residues and their co-localization. RESULTS We have created the AMASS database, which maps 1D sequence annotation databases to 3D(More)
  • Dawn K. Coletta, Latoya E. Campbell, Jennifer Weil, Bruce Kaplan, Marie Clarkson, Jean Finlayson +2 others
  • 2016
INTRODUCTION Decreased insulin sensitivity blunts the normal increase in gene expression from skeletal muscle after exercise. In addition, chronic inflammation decreases insulin sensitivity. Chronic kidney disease (CKD) is an inflammatory state. How CKD and, subsequently, kidney transplantation affects skeletal muscle gene expression after exercise are(More)
  • Samantha E. Day, Richard L. Coletta, Joon Young Kim, Latoya E. Campbell, Tonya R. Benjamin, Lori R. Roust +5 others
  • 2016
Obesity is a metabolic disease caused by environmental and genetic factors. However, the epigenetic mechanisms of obesity are incompletely understood. The aim of our study was to investigate the role of skeletal muscle DNA methylation in combination with transcriptomic changes in obesity. Muscle biopsies were obtained basally from lean (n = 12; BMI = 23.4 ±(More)
  • Qinqin Xu, Yue-xian Hou, Paul Langlais, Patrick Erickson, James Zhu, Chang-Xin Shi +6 others
  • 2016
Immunomodulatory drugs (IMiDs), such as lenalidomide, are therapeutically active compounds that bind and modulate the E3 ubiquitin ligase substrate recruiter cereblon, thereby affect steady-state levels of cereblon and cereblon binding partners, such as ikaros and aiolos, and induce many cellular responses, including cytotoxicity to multiple myeloma (MM)(More)