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Simulation and optimization techniques can provide Design for Six Sigma (DFSS) practitioners with reduced reliance on physical prototypes, rapid time-to-market, minimal defects and post-design rework. These advantages lead to quantifiable benefits within the product development life-cycle, in terms of time and cost. Through one case study, this paper will(More)
In today's competitive market, businesses are adopting new practices like Design for Six Sigma (DFSS), a customer driven, structured methodology for faster-to-market, higher quality, and less costly new products and services. Monte Carlo simulation and stochastic optimization can help DFSS practitioners understand the variation inherent in a new technology,(More)
Clinical photographs of 79 prospectively studied cases of non-familial cutaneous malignant melanoma were reviewed; special attention was directed to the distribution pattern of coexistent melanocytic lesions. A group of 15 patients had moles on the covered buttock area. Seven of these patients had large clinically atypical nevi, and biopsies of these nevi(More)
One hundred forty-one liver scans, 137 brain scans, and 112 bone scans were performed in 192 patients with clinical Stage 1 melanoma. One liver scan was interpreted as abnormal; liver biopsy of that patient showed no metastasis. There were 11 suggestive liver scans; three of the patients with suggestive liver scans had negative liver biopsies. The remaining(More)
The effect of age and nutritional status on the synthesis of fatty acids from a variety of labeled substrates by human adipose tissue in vitro was investigated. The results of this study clearly demonstrate that, although human adipose tissue is able to oxidize glucose to CO2, its ability to incorporate glucose-carbon into long chain fatty acids is(More)
Sixty-two patients with medullary carcinoma of the breast were studied. Mean survival time was 105 months. When identical stages are compared, the five and ten year survival rates for patients with medullary carcinoma of the breast parallel those for patients with infiltrating ductal carcinoma. Age, duration of symptoms, site of the primary lesion, size of(More)
In this large series of patients treated for medullary carcinoma of the breast by radical mastectomy, the over-all five year survival rate was 63.7 per cent and the ten year survival rate, 49.5 per cent. Although survival was adversely affected by axillary lymph node involvement, there was an equal incidence of such involvement, there was an equal incidence(More)
In an increasingly competitive market, businesses are turning to new practices like Six Sigma, a structured methodology for accelerated process improvement, to help reduce costs and increase efficiency. Monte Carlo simulation can help Six Sigma practitioners understand the variation inherent in a process or product, and in turn, can be used to identify and(More)
Cutaneous malignant melanoma has traditionally been treated by "wide" local excision with a 5-cm margin of normal skin about the tumor. The rationale of wide excision for melanoma has never been clearly defined, but the procedure is known to be effective in preventing local recurrence. We studied 105 patients who had 109 primary melanomas in 1977 and(More)