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Cutaneous malignant melanoma has traditionally been treated by "wide" local excision with a 5-cm margin of normal skin about the tumor. The rationale of wide excision for melanoma has never been clearly defined, but the procedure is known to be effective in preventing local recurrence. We studied 105 patients who had 109 primary melanomas in 1977 and(More)
Simulation and optimization techniques can provide Design for Six Sigma (DFSS) practitioners with reduced reliance on physical prototypes, rapid time-to-market, minimal defects and post-design rework. These advantages lead to quantifiable benefits within the product development life-cycle, in terms of time and cost. Through one case study, this paper will(More)
In today's competitive market, businesses are adopting new practices like Design for Six Sigma (DFSS), a customer driven, structured methodology for faster-to-market, higher quality, and less costly new products and services. Monte Carlo simulation and stochastic optimization can help DFSS practitioners understand the variation inherent in a new technology,(More)
In 24 patients undergoing radical mastectomy, the degree of sensitization to breast cancer was compared between lymphocytes obtained from regional lymph nodes and circulating lymphocytes. Using the direct lymphocyte migration inhibition assay a greater immunologic response was observed in regional lymph node lymphocytes as compared to circulating(More)
Clinical photographs of 79 prospectively studied cases of non-familial cutaneous malignant melanoma were reviewed; special attention was directed to the distribution pattern of coexistent melanocytic lesions. A group of 15 patients had moles on the covered buttock area. Seven of these patients had large clinically atypical nevi, and biopsies of these nevi(More)
Sixty-two patients with medullary carcinoma of the breast were studied. Mean survival time was 105 months. When identical stages are compared, the five and ten year survival rates for patients with medullary carcinoma of the breast parallel those for patients with infiltrating ductal carcinoma. Age, duration of symptoms, site of the primary lesion, size of(More)
One hundred forty-one liver scans, 137 brain scans, and 112 bone scans were performed in 192 patients with clinical Stage 1 melanoma. One liver scan was interpreted as abnormal; liver biopsy of that patient showed no metastasis. There were 11 suggestive liver scans; three of the patients with suggestive liver scans had negative liver biopsies. The remaining(More)
In this large series of patients treated for medullary carcinoma of the breast by radical mastectomy, the over-all five year survival rate was 63.7 per cent and the ten year survival rate, 49.5 per cent. Although survival was adversely affected by axillary lymph node involvement, there was an equal incidence of such involvement, there was an equal incidence(More)