Lawrence Gerchikov

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The toxicology of an original Soviet antidepressant inkasan-3-methyl-8-methoxy-3H, 1,2,5,6-tetrahydropyrazino [1,2,3-ab] beta-carboline hydrochloride was studied in different types of experimental animals (mice, rats, rabbits, dogs). It was established that the drug is less toxic than imipramine. The toxic manifestations (seizures, stereotypy) seen in dogs(More)
It has been demonstrated in different species of experimental animals (mice, rats, cats, dogs) that the Soviet drug pyrazidol is a little toxic drug. Prolonged repeated administration of pyrazidol does not exert any damaging action on the vitally important organs and systems of the body. Pyrazidol is less toxic than imipramine.
When I was heated with the ethyl e s t e r of monochloroacet ie acid in benzene in the presence of diethylamine, we obtained 3-benzyl-9-(carbethoxymethyl-3 ,9-diazabicyclo-(3 ,3 ,1)-nonane (II), reduction of which with lithium aluminum hydride yields 3-benzyl-9~fl-hydroxyethyl-3,9-diazabicyclo-(3,3,1)-nonane (III). Debenzy la t ionwi thpa l lad iuminac(More)
In 1963 the new p r e p a r a t i o n a l l o p u r i n o l was p r o p o s e d fo r the t r e a t m e n t of s t a t e s of d i s e a s e a c c o m p a n i e d by an i n c r e a s e d c o n c e n t r a t i o n of u r i c a c id in the o r g a n i s m [1-3]. At the p r e s e n t t i m e , the s u b s t a n c e i s m a r k e t e d a b r o a d u n d e r the n(More)