"Considering usual medical care in clinical trial design".
C oncerns about adverse events, including deaths, in recent large clinical trials, both publicly and privately sponsored, prompted Elias A. discuss " Moving from Observational Studies to Clinical Trials: Why Do We Sometimes Get It Wrong? " (a detailed summary and video archive of the meeting are available at http:⁄⁄www. meetinglink.org/omar/ct/index.htm). "… (More)
Should clinical trial pilot studies be reported? Thebane, Ma, Chu, et al. argue in their discussion of the conduct of pilot studies, that they should be published . Others, such as the editorialist for The Diabetes Educator, take a more cautious approach to publishing pilot studies . I agree with those who advocate publication. I might also note that… (More)
The evolution of the clinical trial dates from the eighteenth century. 10,55 Lind, in his classical study on board the Salisbury, evaluated six treatments for scurvy in 12 patients. One of the two who were given oranges and lemons recovered quickly and was fit for duty after 6 days. The second was the best recovered of the others and was assigned the role… (More)
In a series of 182 twin gestations second-born twins were more often heavier than first-born twins (55%), but overall they weighed less by an average of 21 g. This paradox was shown to be due to the skewed distribution of weight differences favoring the first-born twin, most apparent among pairs in which one or both weighed at least 3000 g. The larger the… (More)