Lawrence Friedman

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C oncerns about adverse events, including deaths, in recent large clinical trials, both publicly and privately sponsored, prompted Elias A. discuss " Moving from Observational Studies to Clinical Trials: Why Do We Sometimes Get It Wrong? " (a detailed summary and video archive of the meeting are available at http:⁄⁄www. "(More)
Should clinical trial pilot studies be reported? Thebane, Ma, Chu, et al. argue in their discussion of the conduct of pilot studies, that they should be published [1]. Others, such as the editorialist for The Diabetes Educator, take a more cautious approach to publishing pilot studies [2]. I agree with those who advocate publication. I might also note that(More)
In a series of 182 twin gestations second-born twins were more often heavier than first-born twins (55%), but overall they weighed less by an average of 21 g. This paradox was shown to be due to the skewed distribution of weight differences favoring the first-born twin, most apparent among pairs in which one or both weighed at least 3000 g. The larger the(More)
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