Lawrence A. Dwyer

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The positions of double bonds in olefins can be readily determined by a sodium borohydride reduction of their methoxymercuration products followed by mass spectrometry. Fragmentation of the methoxy derivative in the mass spectrometer results in cleavage on either side of the methoxy group to give intense fragment ions which are characteristic of each(More)
The source of the oxygen atom in the product of the cytochrome P-450-catalyzed N-demethylation of N-methylcarbazole was determined by mass spectral analysis of the carbinolamine precursor of formaldehyde formed during incubation in oxygen 18-enriched medium. Initial experiments demonstrated that N-(hydroxymethyl)carbazole, the carbinolamine product of the(More)
13C-NMR spectrometry was used to examine the in vivo incorporation of 13C-labeled precursors into 3-methylpentacosane in the cockroach Periplaneta americana. Natural abundance 13C-NMR of 3-methylpentacosane showed that carbons 1 through 6, 23 through 25 and the branching methyl carbon (C26) each gave distinct signals, with carbons 7 through 22(More)
The biosynthesis of (Z,Z)-6,9-heptacosadiene, the major cuticular hydrocarbon component of the American cockroach, was examined by radiotracer and13C-nuclear magnetic resonance (NMR) techniques. Sodium [1-14C] acetate was incorporated about equally into the saturated and diunsaturated hydrocarbons, whereas [1-14C] linoleate preferentially labeled the C27(More)
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