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The functional inhibitory characteristics of the angiotensin II type 1 receptor blockers (ARB) candesartan; irbesartan; and losartan and its active metabolite EXP 3174 (EXP) were studied in rabbit aortic strips and rat portal vein preparations in vitro. Moreover, plasma-protein binding was determined, and the binding was high (>98. 5%) for all ARBs. These(More)
The purpose of the present paper is two-fold. The first is to describe the space of continuous functionals for the Smirnov space Ep(U), p ≥ 1, when U is a simply connected, bounded domain with Ahlfors regular boundary in terms of functions which are analytic in the complement U (or dual complement) and have a prescribed boundary behavior on ∂U . As an(More)
Candesartan is a new angiotensin II type 1 (AT 1 ) receptor blocker. It displays insurmountable antagonism of angiotensin II responses, binding tightly to and dissociating slowly from the AT 1 -receptor. The purpose of this study was to compare the duration of angiotensin II antagonism by the AT 1 -receptor blockers candesartan, irbesartan, losartan and its(More)
The Cauchy problem of the vacuum Einstein’s equations aims to find a semimetric gαβ of a spacetime with vanishing Ricci curvature Rα,β and prescribed initial data. Under the harmonic gauge condition, the equations Rα,β = 0 are transferred into a system of quasi-linear wave equations which are called the reduced Einstein equations. The initial data for(More)
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