Laviña Siemsen

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Smooth muscle cell recruitment is essential for the development of advanced atherosclerotic lesions. Platelet-derived growth factor (PDGF) is a mitogen and chemoattractant for SMCs and it is thought to contribute to atherogenesis because PDGF and PDGF receptor b (PDGFRb) are overexpressed in advanced human lesions compared to normal vessels. Intriguingly,(More)
The title compounds were synthesized (as methyl glycosides) starting from 1,3,4,6-tetra-O-acetyl-2-deoxy-2-fluoro-beta-D-glucopyranose. Stereoselective methods of glycosylation gave, via the tri-O-acetylglycopyranosyl bromide, the methyl 2-deoxy-2-fluoro-alpha- and -beta-D-glucopyranoside triacetates. Each anomer was O-deacetylated and further transformed(More)
Reaction of methyl 3,4-O-isopropylidene-2-O-(trifluoromethylsulfonyl)-alpha-L-fucopyr anoside and its beta anomer with a variety of nucleophilic reagents under mild conditions led to displacement of the triflic ester group, with migration of the ring-oxygen atom to C-2 and entry of the nucleophile at C-1, to give good yields of 2,5-anhydro sugar(More)
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