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Human TRPA1 is intrinsically cold- and chemosensitive with and without its N-terminal ankyrin repeat domain.

• Lavanya Moparthi, Sabeen Survery, +5 authors Peter M Zygmunt
• Proceedings of the National Academy of Sciences…
• 2014

We have purified and reconstituted human transient receptor potential (TRP) subtype A1 (hTRPA1) into lipid bilayers and recorded single-channel currents to understand its inherent thermo- and… (More)

Human TRPA1 is a heat sensor displaying intrinsic U-shaped thermosensitivity

• Lavanya Moparthi, Tatjana I Kichko, +7 authors Peter M Zygmunt
• Scientific reports
• 2016

Thermosensitive Transient Receptor Potential (TRP) channels are believed to respond to either cold or heat. In the case of TRP subtype A1 (TRPA1), there seems to be a species-dependent divergence in… (More)

Photosensitization in Porphyrias and Photodynamic Therapy Involves TRPA1 and TRPV1.

• Alexandru Babes, Susanne K Sauer, +7 authors Michael J M Fischer
• The Journal of neuroscience : the official…
• 2016

UNLABELLED Photosensitization, an exaggerated sensitivity to harmless light, occurs genetically in rare diseases, such as porphyrias, and in photodynamic therapy where short-term toxicity is… (More)

TRPA1–FGFR2 binding event is a regulatory oncogenic driver modulated by miRNA-142-3p

• Jonathan Berrout, Eleni Kyriakopoulou, +27 authors Zahra Timsah
• Nature Communications
• 2017

Recent evidence suggests that the ion channel TRPA1 is implicated in lung adenocarcinoma (LUAD), where its role and mechanism of action remain unknown. We have previously established that the… (More)

A cytochrome c fusion protein domain for convenient detection, quantification, and enhanced production of membrane proteins in Escherichia coli--expression and characterization of cytochrome-tagged…

• Tobias Gustavsson, Maria Trane, +6 authors Cecilia Hägerhäll
• Protein science : a publication of the Protein…
• 2010

Overproduction of membrane proteins can be a cumbersome task, particularly if high yields are desirable. NADH:quinone oxidoreductase (Complex I) contains several very large membrane-spanning protein… (More)

Electrophile and heat activation of truncated mosquito TRPA 1 1 The N-terminal Ankyrin Repeat Domain Is Not Required for Electrophile and Heat Activation of the Purified Mosquito TRPA 1 Receptor

• Sabeen Survery, Lavanya Moparthi, Per Kjellbom, Edward D Högestätt, Peter M Zygmunt, Urban Johanson
• 2016

Temperature sensors are crucial for animals to optimize living conditions. The temperature response of the ion channel transient receptor potential A1 (TRPA1) is intriguing, some orthologs have been… (More)

TRPA 1 – FGFR 2 binding event is a regulatory oncogenic driver modulated by miRNA-1423 p

• Jonathan Berrout, Eleni Kyriakopoulou, +28 authors Zahra Timsah
• 2017

Jonathan Berrout1, Eleni Kyriakopoulou 1, Lavanya Moparthi2, Alexandra S. Hogea3, Liza Berrout4, Cristina Ivan 5, Mihaela Lorger6, John Boyle 7, Chris Peers7, Stephen Muench 3, Jacobo Elies Gomez 7,… (More)

The N-terminal Ankyrin Repeat Domain Is Not Required for Electrophile and Heat Activation of the Purified Mosquito TRPA1 Receptor.

• Sabeen Survery, Lavanya Moparthi, Per Kjellbom, Edward D Högestätt, Peter M Zygmunt, Urban Johanson
• The Journal of biological chemistry
• 2016

Temperature sensors are crucial for animals to optimize living conditions. The temperature response of the ion channel transient receptor potential A1 (TRPA1) is intriguing; some orthologs have been… (More)

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