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Human TRPA1 is intrinsically cold- and chemosensitive with and without its N-terminal ankyrin repeat domain
TLDR
The purified wasabi receptor (TRP subtype A1) is a cold sensor and hTRPA1 is an intrinsically cold- and chemosensitive ion channel, and it is suggested that conformational changes outside the N-terminal ARD by cold, electrophiles, and nonelectrophiles are important in h TRPA1 channel gating and that targeting chemical interaction sites outside theN-terminAL ARD provides possibilities to fine tune TRP1-based drug therapies.
Human TRPA1 is a heat sensor displaying intrinsic U-shaped thermosensitivity
TLDR
It is shown that redox modification and ligands affect human TRPA1 (hTRPA1) cold and heat sensing properties in lipid bilayer and whole-cell patch-clamp recordings as well as heat-evoked TRPA 1-dependent calcitonin gene-related peptide (CGRP) release from mouse trachea.
Photosensitization in Porphyrias and Photodynamic Therapy Involves TRPA1 and TRPV1
TLDR
This study elucidates the underlying molecular transduction mechanism and identifies potential targets of therapy, and suggests a therapeutic use of the pertinent antagonists in clinical development.
Wnt signaling in intestinal inflammation.
The N-terminal Ankyrin Repeat Domain Is Not Required for Electrophile and Heat Activation of the Purified Mosquito TRPA1 Receptor*
TLDR
Recordings of heterologously expressed and purified Anopheles gambiae TRPA1 with and without the N-terminal ankyrin repeat domain demonstrate that both proteins are functional because they responded to the electrophilic compounds allyl isothiocyanate and cinnamaldehyde as well as heat.
TRPA1–FGFR2 binding event is a regulatory oncogenic driver modulated by miRNA-142-3p
TLDR
It is proposed that TRPA1/FGFR2 interaction is functional in LUAD and shown that astrocytes oppose brain metastasis by mediating the downregulation of TRPA 1 through exosome-delivered miRNA-142-3p.
Wnt activator FOXB2 drives the neuroendocrine differentiation of prostate cancer
TLDR
The analyses suggest that FOXB2 imposes a neuronal differentiation program on prostate cancer cells, which is associated with treatment failure and poor prognosis, and is a tissue-specific Wnt activator that promotes the malignant transformation of prostate cancer.
A cytochrome c fusion protein domain for convenient detection, quantification, and enhanced production of membrane proteins in Escherichia coli—Expression and characterization of cytochrome‐tagged
Overproduction of membrane proteins can be a cumbersome task, particularly if high yields are desirable. NADH:quinone oxidoreductase (Complex I) contains several very large membrane‐spanning protein
Human TRPA1 is an inherently mechanosensitive bilayer-gated ion channel
The Transient Receptor Potential Ankyrin 1 (TRPA1) channel is an intrinsic chemo- and thermo-sensitive ion channel with distinct sensory signaling properties. Although a role of TRPA1 in mammalian
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