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Stress reduces the neuroprotective effect of exercise in a rat model for Parkinson's disease
Parkinson's disease (PD) is a progressive neurodegenerative disease of nigrostriatal dopamine (DA) neurons that project from the substantia nigra pars compacta (SNc) to the striatum. To furtherExpand
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Effect of exercise on synaptophysin and calcium/calmodulin-dependent protein kinase levels in prefrontal cortex and hippocampus of a rat model of developmental stress
Stress affects the brain differently depending on the timing, duration and intensity of the stressor. Separation from the dam for 3 h per day is a potent stressor for rat pups which causes activationExpand
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Effect of exercise on learning and memory in a rat model of developmental stress
AbsractAdverse life events occurring in early development can result in long-term effects on behavioural, physiological and cognitive processes. In particular, perinatal stressors impair neurogenesisExpand
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Voluntary running distance is negatively correlated with striatal dopamine release in untrained rats
This study examined the relationship between voluntary running distance and glutamate- and K+-stimulated dopamine release in the striatum (nucleus accumbens and caudate-putamen) of male Long-EvansExpand
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Effect of maternal separation on mitochondrial function and role of exercise in a rat model of Parkinson’s disease
Early life stress, such as maternal separation, causes adaptive changes in neural mechanisms that have adverse effects on the neuroplasticity of the brain in adulthood. As a consequence, children whoExpand
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NMDA-Stimulated Ca2+ Uptake into Barrel Cortex Slices of Spontaneously Hypertensive Rats
The spontaneously hypertensive rat (SHR) is used as a model for attention-deficit hyperactivity disorder (ADHD), since it has behavioural characteristics that resemble the behavioral disturbances ofExpand
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IL-4R{alpha}-responsive smooth muscle cells increase intestinal hypercontractility and contribute to resistance during acute Schistosomiasis.
Interleukin-(IL)-4 and IL-13 signal through heterodimeric receptors containing a common IL-4 receptor-alpha (IL-4Ralpha) subunit, which is important for protection against helminth infections,Expand
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  • Open Access
Tight Coupling of Astrocyte pH Dynamics to Epileptiform Activity Revealed by Genetically Encoded pH Sensors
Astrocytes can both sense and shape the evolution of neuronal network activity and are known to possess unique ion regulatory mechanisms. Here we explore the relationship between astrocyticExpand
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  • Open Access
TNF-dependent regulation and activation of innate immune cells are essential for host protection against cerebral tuberculosis
BackgroundTuberculosis (TB) affects one third of the global population, and TB of the central nervous system (CNS-TB) is the most severe form of tuberculosis which often associates with highExpand
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Development of a Method to Evaluate Glutamate Receptor Function in Rat Barrel Cortex Slices
The rat is a nocturnal animal and uses its vibrissae extensively to navigate its environment. The vibrissae are linked to a highly organized part of the sensory cortex, called the barrel cortex whichExpand
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