Laurie Rolland

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In order to study the kinetics and composition of the polyclonal B-cell activation associated to malaria infection, antigen-specific and non-specific B-cell responses were evaluated in the spleens of mice infected with Plasmodium yoelii 17XL or injected with lysed erythrocytes or plasma from P. yoelii infected mice or with P. falciparum culture(More)
We have analysed by immunoblotting sera from humans and dogs with visceral leishmaniasis, from the Old World as well as the New. When lysates of promastigotes are used as antigens, antibodies against a 94 kDa Leishmania component are detected, regardless of the age and geographical origin of the patient, the serum antibody titre as measured by indirect(More)
Leishmania promastigotes polypeptides are analyzed by immunoblotting with sera from patients infected with different Leishmania species and presenting visceral or cutaneous infections. These sera recognize Leishmania polypeptides in several molecular masses. The major findings of this study are as follow. 1) The Leishmania 94 kDa antigen, which is(More)
UNLABELLED IMMUNITY: The anti-infectious effect of the spleen in general and its anti-malarial effect has been known for a long time. This effect is associated, among other functions, with the spleen's capacity to filter and destroy erythrocytes parasitized by plasmodies or altered by various physical (heat...) or chemical factors. In addition, splenic(More)
“The author(s), and in the case of a Work Made For Hire, as defined in the U.S. Copyright Act, 17 U.S.C. §101, the employer named [below], shall have the following rights (the “Author Rights”): [...] 3. The right to use all or part of the Article, including the APS-prepared version without revision or modification, on the author(s)’ web home page or(More)
We report the identification of a subfraction isolated by gel filtration liquid chromatography from a non-protective Leishmania infantum extract, which protects Balb/c mice against Leishmania major infection, in conjunction with a bacterial adjuvant. Protected mice exhibited cell-mediated immunity, as assessed by increased numbers of CD4+ and CD8+ spleen(More)
BACKGROUND Little is known about residents' performance on the milestones at the institutional level. Our institution formed a work group to explore this using an institutional-level curriculum and residents' evaluation of the milestones. OBJECTIVE We assessed whether beginner-level milestones for interpersonal and communication skills (ICS) related to(More)
Six Plasmodium falciparum protein fractions, isolated under reducing conditions, were used to immunize mice, rabbits and the squirrel monkey Saimiri sciureus. Five or seven subcutaneous injections of each antigenic preparation, in conjunction with Freund's complete or incomplete adjuvants, were administered. This led to the development of specific(More)