Laurie J Goodyear

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Role of AMP-activated protein kinase in mechanism of metformin action.

G. Y. Zhou, Ron Myers, +11 authors David Moller
The Journal of clinical investigation
2001

Metformin is a widely used drug for treatment of type 2 diabetes with no defined cellular mechanism of action. Its glucose-lowering effect results from decreased hepatic glucose production and… (More)

Evidence for 5' AMP-activated protein kinase mediation of the effect of muscle contraction on glucose transport.

Takuma Hayashi, Michael F. Hirshman, E J Kurth, William Winder, Laurie J Goodyear
Diabetes
1998

The intracellular signaling proteins that lead to exercise-stimulated glucose transport in skeletal muscle have not been identified, although it is clear that there are separate signaling mechanisms… (More)

A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance.

Jens C. Brüning, Mervyn Dodson Michael, +5 authors C Ronald Kahn
Molecular cell
1998

Skeletal muscle insulin resistance is among the earliest detectable defects in humans with type 2 diabetes mellitus. To determine the contribution of muscle insulin resistance to the metabolic… (More)

Discovery of TBC1D1 as an insulin-, AICAR-, and contraction-stimulated signaling nexus in mouse skeletal muscle.

Eric B. Taylor, Ding Ding An, +8 authors Laurie J Goodyear
The Journal of biological chemistry
2008

The Akt substrate of 160 kDa (AS160) is phosphorylated on Akt substrate (PAS) motifs in response to insulin and contraction in skeletal muscle, regulating glucose uptake. Here we discovered a… (More)

Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade.

Mark E Griffin, Maura Marcucci, +7 authors Gerald I Shulman
Diabetes
1999

To examine the mechanism by which free fatty acids (FFAs) induce insulin resistance in vivo, awake chronically catheterized rats underwent a hyperinsulinemic-euglycemic clamp with or without a 5-h… (More)

Diet and exercise signals regulate SIRT3 and activate AMPK and PGC-1α in skeletal muscle

Orsolya M. Palacios, J. J. Carmona, +5 authors Qiang Guo Tong
Aging
2009

SIRT3 is a member of the sirtuin family of NAD(+)-dependent deacetylases, which is localized to the mitochondria and is enriched in kidney, brown adipose tissue, heart, and other metabolically active… (More)

Highly Efficient, Functional Engraftment of Skeletal Muscle Stem Cells in Dystrophic Muscles

Massimiliano Cerletti, Sara Jurga, +4 authors Amy J. Wagers
Cell
2008

Satellite cells reside beneath the basal lamina of skeletal muscle fibers and include cells that act as precursors for muscle growth and repair. Although they share a common anatomical localization… (More)

Metabolic stress and altered glucose transport: activation of AMP-activated protein kinase as a unifying coupling mechanism.

Takuma Hayashi, Michael F. Hirshman, Nobuharu Fujii, Susan Amy Habinowski, Lee Alan Witters, Laurie J Goodyear
Diabetes
2000

5'AMP-activated protein kinase (AMPK) can be activated in response to cellular fuel depletion and leads to switching off ATP-consuming pathways and switching on ATP-regenerating pathways in many cell… (More)

Brown adipose tissue regulates glucose homeostasis and insulin sensitivity.

Kristin I Stanford, Roeland J. W. Middelbeek, +8 authors Laurie J Goodyear
The Journal of clinical investigation
2013

Brown adipose tissue (BAT) is known to function in the dissipation of chemical energy in response to cold or excess feeding, and also has the capacity to modulate energy balance. To test the… (More)

Distinct signals regulate AS160 phosphorylation in response to insulin, AICAR, and contraction in mouse skeletal muscle.

Henning Fritz Kramer, Carol A Witczak, +6 authors Laurie J Goodyear
Diabetes
2006

Insulin and contraction increase GLUT4 translocation in skeletal muscle via distinct signaling mechanisms. Akt substrate of 160 kDa (AS160) mediates insulin-stimulated GLUT4 translocation in L6… (More)

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