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Phosphorylation of the serine-threonine kinase RIP3 is required for the recruitment of the effector protein Mlkl to the RIP1-RIP3 necrosome complex and necroptosis. In Nature Cell Biology, Han and(More)
High concentrations of vitamin C are found in the central nervous system. In Science Signaling, Portugal et al. show that brain-resident microglia require vitamin C for homeostasis. Microglia import(More)
Infection can result in two different responses by the host, one focused on elimination and the other focused on ‘tolerance’ (defined here as coexistence with the infection with few or no sequelae).(More)